292600-22-7

Usage

Uses

Used in Organic Synthesis:
2-Pyridineacetic acid, 5-nitro-, methyl ester is used as a building block in organic synthesis for the production of various chemical products. Its reactivity with different reagents allows for the creation of a wide range of compounds.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, 2-Pyridineacetic acid, 5-nitro-, methyl ester is used as a key intermediate in the synthesis of certain drugs. Its unique chemical properties make it a valuable component in the development of new medications.
Used in Agrochemical Production:
2-Pyridineacetic acid, 5-nitro-, methyl ester is also utilized in the agrochemical sector for the development of insecticides and other biologically active compounds. Its potential applications in this field contribute to the creation of effective pest control solutions.
Used in Research and Development:
Due to its unique chemical properties and reactivity, 2-Pyridineacetic acid, 5-nitro-, methyl ester is used in research and development for exploring new chemical reactions and discovering novel applications in various industries.

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 42726-73-8 methyl t-butyl malonate 
• 68719-87-9 dimethyl 2-(5-nitropyridin-2-yl)malonate 
• 292600-21-6 (2-(5-nitropyridin-2-yl)malonate 1-(tert-butyl)-3-methyl ester) 

Downstream Products

• 174891-11-3 methyl 2-(5-aminopyridin-2-yl)acetate 
• 1260740-65-5 2-(5-nitropyridin-2-yl)ethanol 

Relevant academic research and scientific papers

BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS

Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

External-Photocatalyst-Free Visible-Light-Mediated Synthesis of Indolizines

A visible-light-mediated synthesis of valuable polycyclic indolizine heterocycles from easily accessed brominated pyridine and enol carbamate derivatives has been developed. This process, which operates at room temperature under irradiation from readily available light sources, does not require the addition of an external photocatalyst. Instead, an investigation into the reaction mechanism indicates that the indolizine products themselves may be in some way involved in mediating and accelerating their own formation. Preliminary studies also show that these simple heterocyclic compounds may be capable of facilitating other visible-light-mediated transformations.

COMPOUNDS AND THEIR METHODS OF USE

Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.

COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES AS GLUTAMINASE INHIBITORS FOR TREATING CANCERS THEREOF

Provided are compounds of formula (I), wherein X, Y, Z, W, m, n, o, p, R1, R2 and R6 are defined as in the description. Pharmaceutical compositions and uses as glutaminase inhibitors for treating cancers thereof are also provided.

COMPOUNDS AND THEIR METHODS OF USE

Provided are compounds of formula (I), which can inhibit glutaminase. Pharmaceutical compositions comprising these compounds and uses as glutaminase inhibitors for treating cancers thereof are also provided.

Total syntheses of 6- and 7-azaindole derived GnRH antagonists

The palladium(0)-catalyzed heteroannulation of a triethylsilyl alkyne and an ortho-aminoiodopyridine derivative is used as the key step in a highly convergent route to 6- and 7-azaindoles of biological interest.

6-AZAINDOLE COMPOUNDS AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE

There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.