68719-87-9

Basic information

• Product Name: diMethyl 2-(5-nitropyridin-2-yl)Malonate
• Synonyms: diMethyl 2-(5-nitropyridin-2-yl)Malonate
• CAS NO: 68719-87-9
• Molecular Formula: C10H10N2O6
• Molecular Weight: 254.1962
• EINECS: -0
• Mol File: 68719-87-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: diMethyl 2-(5-nitropyridin-2-yl)Malonate(CAS DataBase Reference)
• NIST Chemistry Reference: diMethyl 2-(5-nitropyridin-2-yl)Malonate(68719-87-9)
• EPA Substance Registry System: diMethyl 2-(5-nitropyridin-2-yl)Malonate(68719-87-9)

Safety Data

• Hazardous Substances Data: 68719-87-9(Hazardous Substances Data)

Usage

General Description

DiMethyl 2-(5-nitropyridin-2-yl)Malonate is a chemical compound with the molecular formula C11H10N2O6. It is a yellow to orange solid with a molecular weight of 258.21 g/mol. diMethyl 2-(5-nitropyridin-2-yl)Malonate is commonly used as a building block in the synthesis of various organic molecules. It is a derivative of malonic acid and contains a nitro group attached to a pyridine ring. DiMethyl 2-(5-nitropyridin-2-yl)Malonate has potential applications in the pharmaceutical and agrochemical industries, as well as in academic research. Its unique structure and reactivity make it a valuable intermediate in the production of a wide range of organic compounds.

Upstream product

• 456-24-6 2-Fluoro-5-nitropyridine 
• 108-59-8 malonic acid dimethyl ester 
• 4548-45-2 2-chloro-5-nitropyridine 

Downstream Products

• 292600-22-7 methyl 2-(5-nitropyridin-2-yl)acetate 
• 174891-11-3 methyl 2-(5-aminopyridin-2-yl)acetate 

Relevant articles and documents

External-Photocatalyst-Free Visible-Light-Mediated Synthesis of Indolizines

A visible-light-mediated synthesis of valuable polycyclic indolizine heterocycles from easily accessed brominated pyridine and enol carbamate derivatives has been developed. This process, which operates at room temperature under irradiation from readily available light sources, does not require the addition of an external photocatalyst. Instead, an investigation into the reaction mechanism indicates that the indolizine products themselves may be in some way involved in mediating and accelerating their own formation. Preliminary studies also show that these simple heterocyclic compounds may be capable of facilitating other visible-light-mediated transformations.

COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES AS GLUTAMINASE INHIBITORS FOR TREATING CANCERS THEREOF

Provided are compounds of formula (I), wherein X, Y, Z, W, m, n, o, p, R1, R2 and R6 are defined as in the description. Pharmaceutical compositions and uses as glutaminase inhibitors for treating cancers thereof are also provided.

ANDROGEN RECEPTOR ANTAGONISTS AND USES THEREOF

Disclosed are substituted thioimidazolidinone compounds and pharmaceutical compositions comprising such compounds. The compounds and compositions can be used for treatment of androgen receptor-associated diseases or disorders, such as prostate cancer, benign prostatic hypertrophy, male hair loss and hypertrichosis.