68719-87-9

Usage

Uses

Used in Pharmaceutical Industry:
DiMethyl 2-(5-nitropyridin-2-yl)Malonate is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key intermediate in the production of a wide range of organic molecules, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, DiMethyl 2-(5-nitropyridin-2-yl)Malonate serves as a crucial component in the synthesis of various agrochemical products. Its reactivity and structural properties make it an essential intermediate for creating effective and innovative solutions for agricultural applications.
Used in Academic Research:
DiMethyl 2-(5-nitropyridin-2-yl)Malonate is also utilized in academic research as a valuable intermediate for studying organic synthesis and exploring new chemical reactions. Its unique properties provide researchers with opportunities to investigate novel pathways and mechanisms in organic chemistry.

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 108-59-8 malonic acid dimethyl ester 
• 456-24-6 2-Fluoro-5-nitropyridine 

Downstream Products

• 174891-11-3 methyl 2-(5-aminopyridin-2-yl)acetate 
• 292600-22-7 methyl 2-(5-nitropyridin-2-yl)acetate 

Relevant academic research and scientific papers

External-Photocatalyst-Free Visible-Light-Mediated Synthesis of Indolizines

A visible-light-mediated synthesis of valuable polycyclic indolizine heterocycles from easily accessed brominated pyridine and enol carbamate derivatives has been developed. This process, which operates at room temperature under irradiation from readily available light sources, does not require the addition of an external photocatalyst. Instead, an investigation into the reaction mechanism indicates that the indolizine products themselves may be in some way involved in mediating and accelerating their own formation. Preliminary studies also show that these simple heterocyclic compounds may be capable of facilitating other visible-light-mediated transformations.

COMPOUNDS AND THEIR METHODS OF USE

Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.

COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES AS GLUTAMINASE INHIBITORS FOR TREATING CANCERS THEREOF

Provided are compounds of formula (I), wherein X, Y, Z, W, m, n, o, p, R1, R2 and R6 are defined as in the description. Pharmaceutical compositions and uses as glutaminase inhibitors for treating cancers thereof are also provided.

COMPOUNDS AND THEIR METHODS OF USE

Provided are compounds of formula (I), which can inhibit glutaminase. Pharmaceutical compositions comprising these compounds and uses as glutaminase inhibitors for treating cancers thereof are also provided.

ANDROGEN RECEPTOR ANTAGONISTS AND USES THEREOF

Disclosed are substituted thioimidazolidinone compounds and pharmaceutical compositions comprising such compounds. The compounds and compositions can be used for treatment of androgen receptor-associated diseases or disorders, such as prostate cancer, benign prostatic hypertrophy, male hair loss and hypertrichosis.

GAMMA SECRETASE MODULATORS

The present invention provides compounds that are gamma secretase modulators and are therefore useful for the treatment of diseases treatable by modulation of gamma secretase such as Alzheimer's disease. Also provided are pharmaceutical compositions conta