292609-38-2Relevant academic research and scientific papers
Synthesis and anti-bacterial activity of a library of 1,2-benzisothiazol-3(2H)-one (BIT) derivatives amenable of crosslinking to polysaccharides
Viani, Fiorenza,Rossi, Bianca,Panzeri, Walter,Merlini, Luca,Martorana, Alessandra M.,Polissi, Alessandra,Galante, Yves M.
, p. 1745 - 1761 (2017)
1,2-Benzisothiazol-3(2H)-one (BIT) is one of the most common chemical biocides in industrial products, with a heterocyclic structure and a wide range of antimicrobial activity. A library of BIT derivatives was synthesized and characterized, from which 18 compounds were selected, tested for anti-bacterial activity relative to the parent molecule and amenable of coupling to plant polysaccharides in general and to galactomannans (GM) in particular, widely used as rheology modifiers, but with limited “biostability”. Four sites on the BIT core were targeted: the nitrogen and the oxygen atoms on the heterocyclic ring, the C5 and the C6 positions on the aromatic ring, where functional groups were introduced. The ultimate aim of this work is to establish whether by covalently linking a biocide to GM polymers, their “biostability” can be improved.
Synthesis of benzolactams by 11-endo selective aryl radical cyclisation of 2-iodobenzamides
Prado, Maria A.F.,Alves, Ricardo J.,Souza Jr., Jose D.,Alves, Rosemeire B.,Pedrosa, Maria T.C.,Prado, Renata F.,Faraco, Andre A.G.
, p. 1853 - 1857 (2007/10/03)
Regioselective 11-endo aryl radical cyclisation of methyl 4-O-allyl-2,3-di-O-benzyl-6-deoxy-6-(2-iodobenzoylamino)-α-D- glucopyranoside 4 and N-(3-allyloxypropyl)-2-iodobenzamide 9 with tri-n-butyltin hydride provided the benzolactams 5 and 10, respectively. The unequivocal structures of 5 and 10 were supported by 1H and 13C NMR spectroscopy and by PENDANT or DEPT, COSY and HMQC experiments. The Royal Society of Chemistry 2000.
