292638-37-0Relevant articles and documents
Covalent Occlusion of the RORγt Ligand Binding Pocket Allows Unambiguous Targeting of an Allosteric Site
Meijer, Femke A.,Van Den Oetelaar, Maxime C. M.,Doveston, Richard G.,Sampers, Ella N. R.,Brunsveld, Luc
supporting information, p. 631 - 639 (2021/04/07)
The nuclear receptor RORγt is a key positive regulator in the differentiation and proliferation of T helper 17 (Th17) cells and the production of proinflammatory cytokines like IL-17a. Dysregulation of this pathway can result in the development of various
NEW PLASMA LIPID LOWERING AGENTS
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Page/Page column 21; 22, (2015/12/24)
The present invention relates to new plasma lipid lowering compounds and pharmacological compositions,and their use in the prophylaxis, prevention and treatment of hyperlipidemia, including hypertriglyceridemia, hyperlipoproteinemia, and hypercholesterolemia, as well as hyperlipidemia-related diseases.
PPAR-gamma modulator
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, (2008/06/13)
A compound of the following formula or a pharmacologically acceptable salt thereof: 1 wherein A represents a phenyl group or the like, B represents an aryl group or the like, X represents an oxygen atom or the like, and n represents 0 or 1. The compound is a PPAR γ modulator which is a therapeutic agent for retrograde osteoporosis in which excessive differentiation of adipocytes is inhibited and formation and differentiation of osteoblasts from stem cells is facilitated, and for diabetes mellitus without characteristics such as excessive adipogenesis, liver dysfunction, vascular disorders, heart diseases and the like.