29277-73-4

Basic information

• Product Name: 2-[4-[(2RS)-2-HYDROXY-3[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETONITRILE
• Synonyms: ATENOLOL IMPURITY H;ATENOLOL IMP H;4-(2-HYDROXY-3-ISOPROPYLAMINOPROPOXY) PHENYLACETONITRILE;2-[4-[(2RS)-2-HYDROXY-3[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETONITRILE;2-(4-(2-hydroxy-3-(isopropylaMino)propoxy)phenyl)acetonitrile;Atenolol IMpurity –H(EP);Atenolol Related CoMpound B;4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetonitrile
• CAS NO: 29277-73-4
• Molecular Formula: C₁₄H₂₀N₂O₂
• Molecular Weight: 248.32
• Product Categories: Amines, Aromatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 29277-73-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 448.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.083±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 13.83±0.20(Predicted)
• CAS DataBase Reference: 2-[4-[(2RS)-2-HYDROXY-3[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-[(2RS)-2-HYDROXY-3[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETONITRILE(29277-73-4)
• EPA Substance Registry System: 2-[4-[(2RS)-2-HYDROXY-3[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETONITRILE(29277-73-4)

Safety Data

• Hazardous Substances Data: 29277-73-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 29277-73-4 differently. You can refer to the following data:
1. 2-[4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetonitrile is an impurity of Atenolol (A790075), a cardioselective β-adrenergic blocker.
2. 2-[4-[(2RS)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetonitrile is an impurity of Atenolol (A790075), a cardioselective β-adrenergic blocker. Atenolol EP Impurity H

Upstream product

• 29122-68-7 (RS)-atenolol 
• 35198-42-6 1-(4'-Cyanomethylphenoxy)-2,3-epoxypropane 
• 75-31-0 isopropylamine 
• 14191-95-8 4-cyanomethylphenol 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 6452-58-0 Isopropyl-oxiranylmethyl-amine 

Downstream Products

• 29122-68-7 (RS)-atenolol 
• 29112-40-1 ethyl 4-(2-hydroxy-3-isopropyl-amino)-propoxy phenylacetate 

Relevant articles and documents

Mechanistic Insight Facilitates Discovery of a Mild and Efficient Copper-Catalyzed Dehydration of Primary Amides to Nitriles Using Hydrosilanes

Metal-catalyzed silylative dehydration of primary amides is an economical approach to the synthesis of nitriles. We report a copper-hydride(CuH)-catalyzed process that avoids a typically challenging 1,2-siloxane elimination step, thereby dramatically increasing the rate of the overall transformation relative to alternative metal-catalyzed systems. This new reaction proceeds at ambient temperature, tolerates a variety of metal-, acid-, or base-sensitive functional groups, and can be performed using a simple ligand, inexpensive siloxanes, and low catalyst loading.

Attempts to synthesize new β1 receptor blockers

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