35198-42-6

Basic information

• Product Name: 4-(2-OxiranylMethoxy)benzeneacetonitrile
• Synonyms: 4-(2-OxiranylMethoxy)benzeneacetonitrile
• CAS NO: 35198-42-6
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.21054
• Product Categories: Amines, Aromatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 35198-42-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(2-OxiranylMethoxy)benzeneacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-OxiranylMethoxy)benzeneacetonitrile(35198-42-6)
• EPA Substance Registry System: 4-(2-OxiranylMethoxy)benzeneacetonitrile(35198-42-6)

Safety Data

• Hazardous Substances Data: 35198-42-6(Hazardous Substances Data)

Usage

Uses

4-(2-Oxiranylmethoxy)benzeneacetonitrile is an intermediate for the synthesis of Atenolol (A790075), a cardioselective β-adrenergic blocker.

Upstream product

• 623-05-2 (4-hydroxyphenyl)methanol 

Downstream Products

• 29122-68-7 (RS)-atenolol 
• 29277-73-4 1-(4'-cyanomethylphenoxy)-2-hydroxy-3-(isopropylamino)propane 

Relevant articles and documents

A synthesis of atenolol using a nitrile hydration catalyst

The synthesis of atenolol is described using a platinum containing homogeneous catalyst for the conversion of a nitrile to an amide. The catalytic reaction may be employed as the final step in the synthesis or in the preparation of the intermediate 4-hydroxyphenylacetamide. The structure of the nitrile intermediate, 1-(4′-cyanomethylphenoxy)-2-hydroxy-3-isopropylaminopropane, has been determined by X-ray crystallography.