29284-28-4Relevant academic research and scientific papers
One-step formation both of C-N and of C-O bonds of N-alkoxyamides through NHC-catalyzed three-component reactions of enals, nitrosoarenes, and enones
Sun, Zhong-Xin,Cheng, Ying
, p. 4982 - 4987 (2013/01/14)
NHC-catalyzed three-component reactions of α,β-unsaturated aldehydes (enals), nitrosoarenes, and α,β-unsaturated ketones (enones) were studied. The reactions proceeded through a cascade aza-benzoin condensation/oxo-Michael addition sequence to produce N,O-bisfunctionalized N-hydroxylacrylamides in moderate to good yields. This work not only provides an efficient method for the one-step formation both of the C-N and of the C-O bonds in N-alkoxyamides, but also advances the application of NHC organocatalysis in the field of multicomponent reactions. NHC-catalyzed three-component reactions of α,β-unsaturated aldehydes (enals), nitrosoarenes, and α,β-unsaturated ketones (enones) proceeded through a cascade aza-benzoin condensation/oxo-Michael addition sequence to produce N,O-bisfunctionalized N-hydroxylacrylamides in moderate to good yields. Copyright
