29284-29-5

Upstream product

• 22731-70-0 1-(4-bromophenyl)prop-2-en-1-one 
• 1516-21-8 4-methoxynitrosobenzene 
• 104-55-2 3-phenyl-propenal 
• 7448-86-4 1-(4-methoxyphenyl)prop-2-en-1-one 
• 19832-78-1 1-(4-methylphenyl)prop-2-en-1-one 
• 768-03-6 Phenyl vinyl ketone 

Relevant academic research and scientific papers

One-step formation both of C-N and of C-O bonds of N-alkoxyamides through NHC-catalyzed three-component reactions of enals, nitrosoarenes, and enones

NHC-catalyzed three-component reactions of α,β-unsaturated aldehydes (enals), nitrosoarenes, and α,β-unsaturated ketones (enones) were studied. The reactions proceeded through a cascade aza-benzoin condensation/oxo-Michael addition sequence to produce N,O-bisfunctionalized N-hydroxylacrylamides in moderate to good yields. This work not only provides an efficient method for the one-step formation both of the C-N and of the C-O bonds in N-alkoxyamides, but also advances the application of NHC organocatalysis in the field of multicomponent reactions. NHC-catalyzed three-component reactions of α,β-unsaturated aldehydes (enals), nitrosoarenes, and α,β-unsaturated ketones (enones) proceeded through a cascade aza-benzoin condensation/oxo-Michael addition sequence to produce N,O-bisfunctionalized N-hydroxylacrylamides in moderate to good yields. Copyright