29304-66-3Relevant articles and documents
Nickel-Catalyzed Kumada Coupling of Boc-Activated Aromatic Amines via Nondirected Selective Aryl C-N Bond Cleavage
Zhang, Zheng-Bing,Ji, Chong-Lei,Yang, Ce,Chen, Jie,Hong, Xin,Xia, Ji-Bao
, p. 1226 - 1231 (2019/02/14)
A nickel-catalyzed Kumada coupling of aniline derivatives was developed by selective cleavage of aryl C-N bonds under mild reaction conditions. Without preinstallation of an ortho directing group on anilines, the cross-coupling reactions of Boc-protected aromatic amines with aryl Grignard reagents afforded unsymmetric biaryls. Mechanistic studies by DFT calculations revealed that the nickel-mediated C-N bond cleavage is the rate-limiting step.
Methylation of Arenols through Ni-catalyzed C—O Activation with Methyl Magnesium Bromide
Shi, Wen-Juan,Shi, Zhang-Jie
supporting information, p. 183 - 186 (2018/01/15)
Direct alkylation of arenols with alkyl organometallic reagents has never been approached. Herein we reported the first successful example of nickel-catalyzed methylation of arenols with methyl Grignard reagents to construct C(sp2)-C(sp3/
Nickel-Catalyzed Borylation of Aryl and Benzyl 2-Pyridyl Ethers: A Method for Converting a Robust ortho-Directing Group
Tobisu, Mamoru,Zhao, Jiangning,Kinuta, Hirotaka,Furukawa, Takayuki,Igarashi, Takuya,Chatani, Naoto
, p. 2417 - 2421 (2016/08/16)
The nickel-catalyzed borylation of aryl 2-pyridyl ethers via the loss of a 2-pyridyloxy group is described. This method allows a 2-pyridyloxy group to be used as a convertible directing group in C?H bond functionalization reactions. The nickel catalyst can also borylate arylmethyl 2-pyridyl ethers, in which the stereochemistry at the benzylic position is retained in the case of chiral secondary benzylic substrates. (Figure presented.).