2931-89-7Relevant academic research and scientific papers
Containing 8-ethoxy-3-nitro -2H-benzopyran structure of the hydrazone derivatives and the preparation method and application
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Paragraph 0037-0040, (2017/01/05)
The invention belongs to the technical field of chemistry, and relates to acylhydrazone derivatives with an 8-ethoxy-3-nitro-2H-benzopyran structure as well as a preparation method and application thereof. The structural general formula (I) of the derivatives is as shown in the specification, wherein R1 is independent aryl or substituted aryl with 6-10 carbon atoms, or heteroaryl or substituted heteroaryl with 5-10 atoms; R2 is independent H, methyl or ethyl. Ethyl vanillin is used as a raw material, the acylhydrazone derivatives with the 8-ethoxy-3-nitro-2H-benzopyran structure are synthesized through acylation, cyclization and condensation, and anti-tumor activity experiment researches are performed. Experimental results show that the compounds disclosed by the invention have good tumor cell proliferation activity resistance.
Process for the preparation of 3-carboxy-4-hydroxybenzaldehides and derivatives thereof
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, (2008/06/13)
The present invention concerns a process for the preparation of 3-carboxy-4-hydroxybenzaldehydes and derivatives thereof from phenolic compounds carrying formyl and/or hydroxymethyl groups in the 2 and 4 positions. The invention also concerns the preparation of 4-hydroxybenzaldehydes from 3-carboxy-4-hydroxybenzaldehydes. More particularly, the invention concerns the preparation of 3-methoxy-4-hydroxybenzaldehyde and 3-ethoxy-4-hydroxybenzaldehyde, respectively known as "vanillin" and "ethylvanillin". The process for the preparation of 3-carboxy-4-hydroxybenzaldehyde is characterized in that the group in the 2 position in a phenolic compound carrying formyl and/or hydroxymethyl groups in the 2 and 4 positions is selectively oxidized to a carboxy group, and optionally a hydroxymethyl group in the 4 position is selectively oxidized to a formyl group. A successive decarboxylation step for a 3-carboxy-4-hydroxybenzaldehyde produces a 4-hydroxybenzaldehyde.
