2936-63-2

Usage

Uses

Used in Pharmaceutical Research:
Naphthalen-1-yl(phenyl)methanamine is used as a research chemical for studying the effects of psychoactive substances and their potential applications in the development of new medications. Its structural similarity to methamphetamine allows researchers to investigate its pharmacological properties and compare them with other amphetamine derivatives.
Used in Forensic Toxicology:
In forensic toxicology, naphthalen-1-yl(phenyl)methanamine can be used as a reference compound for the identification and analysis of designer drugs in biological samples. This helps in understanding the prevalence of drug abuse and the potential risks associated with these substances.
Used in Controlled Substance Regulation:
As a controlled substance, naphthalen-1-yl(phenyl)methanamine is used in the development and enforcement of regulations and policies related to the prevention of drug abuse and trafficking. This includes monitoring its production, distribution, and consumption to ensure public safety and compliance with legal standards.

Upstream product

• 92-29-5 hydrobenzamide 
• 703-55-9 1-naphthylmagnesiumbromide 
• 1069136-41-9 N-(1-naphthylmethyl)xanthone imine 
• 108-90-7 chlorobenzene 
• 41839-61-6 1-(1-naphthyl)-1-(2-(1-hydroxyphenyl))methylenimine 
• 86-53-3 1-Cyanonaphthalene 

Downstream Products

• 1517-61-9 (S)-1-naphthyl(phenyl)methanol 
• 857829-29-9 ([1]naphthyl-phenyl-methyl)-carbamic acid ethyl ester 
• 841-86-1 phenyl(1-naphthyl)diazomethane 
• 642-29-5 1-benzoylnaphthalene 

Relevant academic research and scientific papers

Hydrogen bond directed aerobic oxidation of amines via photoredox catalysis

An application of H-bonding interactions for directing the α-C-H oxidation of amines to amides and amino-ketones catalyzed by an organic photocatalyst is reported. The high efficiency of this method is demonstrated by the aerobic oxidation of pyrrolidines, diarylamines and benzylamines bearing urea groups with high yields and a wide substrate scope.

Carbon-carbon bond formations at the benzylic positions of N-benzylxanthone imines and N-benzyldi-1-naphthyl ketone imine

Two N-benzyl imines are designed to allow for carbon-carbon bond formations at the aminated benzylic positions. Direct benzylic arylation reactions of N-benzylxanthone imine with aryl chlorides proceed under palladium catalysis in the presence of cesium hydroxide, yielding the corresponding benzhydrylamine derivatives. Alkylation reactions of N-benzyldi-1-naphthyl ketone imine with alkyl halides in the presence of potassium tert-butoxide afford the corresponding 1-phenylalkylamines in high yields. Conjugate addition of N-benzyldi-1-naphthyl ketone imine is also described.

BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS

The present invention relates to Bicyclic Heterocycle Derivatives of formula (I), compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of GPR1 19 in a patient.

Palladium-catalyzed benzylic arylation of N-benzylxanthone imine

(Chemical Equation Presented) The direct benzylic arylation of N-benzylxanthone imine with aryl chloride proceeds under palladium catalysis, yielding the corresponding coupling product. The product is readily transformed to benzhydrylamine. Taking into consideration that the imine is readily available from benzylic amine, the overall transformation represents a formal cross-coupling reaction of aryl halide with α-aminobenzyl metal.