29366-77-6

Usage

Uses

Used in Pharmaceutical Industry:
6-(2-chlorophenyl)-1,3,5-triazine-2,4-diamine is used as a superoxide dismutase inhibitor for the modulation of neurodegenerative diseases. Its ability to inhibit superoxide dismutase activity makes it a potential therapeutic agent for conditions such as Alzheimer's, Parkinson's, and other neurodegenerative disorders, where oxidative stress and free radical damage contribute to the progression of the disease.

InChI:InChI=1/C9H8ClN5/c10-6-4-2-1-3-5(6)7-13-8(11)15-9(12)14-7/h1-4H,(H4,11,12,13,14,15)

Upstream product

• 873-32-5 2-Chlorobenzonitrile 
• 127099-85-8 N-Cyanoguanidine 
• 1115-70-4 metformin hydrochloride 

Relevant academic research and scientific papers

2,4,6-trisubstituted-1,3,5-s-triazine compound and preparation and application thereof

The invention provides a 2,4,6-trisubstituted-1,3,5-s-triazine compound as well as preparation and application thereof, and biguanide or dimethyl biguanide hydrochloride is used as an initial raw material to react with a cyano compound under an alkaline condition to prepare the 2,4,6-trisubstituted-1,3,5-s-triazine compound. The invention provides a simple and convenient synthetic method of a 2,4,6-trisubstituted-1,3,5-s-triazine compound, and the compound provided by the invention can be applied to preparation of an anti-myelogenous leukemia medicine, namely an enasidenib medicine. Compared with the prior art, the method for preparing the enasidenib has the advantages that two-step reaction is reduced, the use of a halogenating reagent is avoided, and the method is a green and environment-friendly chemical process. The structural formula I is shown in the specification.

Synthesis, molecular docking studies, and in vitro evaluation of 1,3,5-triazine derivatives as promising antimicrobial agents

The six-membered ring heterocycle 1,3,5-triazine and its derivatives have attracted considerable attention as they have proven to be excellent bioactive herbicides, cancer agents, etc. A series of 1,3,5-triazine derivatives (3a-o) were synthesized by a single step reaction and characterized by 1H NMR, 13C NMR, and mass spectrometry analysis. Antimicrobial screening of title compounds (3a-o) was examined against five bacterial and two fungal strains. In vitro study revealed that the freshly synthesized 6-(thiazol-4-yl)-1,3,5-triazine-2,4-diamine (3o) showed good antibacterial growth inhibition against E. coli, K. pneumoniae, and A. baumannii bacterial strains, and even the fungi C. neoformans. Molecular docking studies were performed on the X-ray crystal structure of E. coli 24 kDa domain in complex with clorobiocin (PDB code: 1KZN; resolution 2.30 ?) using Surflex-Dock program of Sybyl-X software. The results obtained are very encouraging.

Microwave-assisted clean synthesis of 6-aryl-2,4-diamino-1,3,5-triazines in [bmim][PF6]

An efficient and green approach was developed to prepare 6-aryl-2,4-diamino-1,3,5-triazines from corresponding arylnitriles and dicyanodiamide in ionic liquid [bmim][PF6] under computer-controlled microwave irradiation. Particularly valuable features of this method included the short reaction time, good yield, convenient operation and eco-friendly solvent.

ANTICANCER COMPOSITION AND COMPOUND

An anticancer composition containing a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof. In formula (I), R10 and R20 may be the same or different from each other and each represents hydrogen, halogen, amino, aralkylamino, nitro, lower alkyl, lower alkoxy, lower alkoxyalkoxy, lower aralkyloxy or acyl; R30 and R40 may be the same or different from each other and each represents hydrogen, nicotinoyl, benzoyl or lower alkoxy; and n represents 0 or 1.