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1115-70-4

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Factroy Supply 99% Metformin Hydrochloride powder in stock
Cas No: 1115-70-4
No Data 1 Kilogram 1 Metric Ton/Month Shaanxi Mingqi Chemical Co., Ltd Contact Supplier
Metformin hydrochloride,high quality,CAS NO.1115-70-4
Cas No: 1115-70-4
No Data 1 Metric Ton 10 Metric Ton/Month Shaanxi WuZhiYuan Biological Technology Co.,Ltd Contact Supplier
Metformin hydrochloride
Cas No: 1115-70-4
No Data 1 Metric Ton 100 Metric Ton/Day Shanghai AngewChem Co., Ltd. Contact Supplier
Metformin Hydrochloride(HCL)as Active Pharmaceutical Ingredient CAS 1115-70-4
Cas No: 1115-70-4
USD $ 2.0-2.0 / Gram 100 Gram 100 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
High purity Various Specifications Metformin HCL CAS:1115-70-4
Cas No: 1115-70-4
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Good quality Metformin Hcl//1115-70-4 manufacturer
Cas No: 1115-70-4
No Data 1 Kilogram 200 Metric Ton/Month Hefei TNJ chemical industry co.,ltd Contact Supplier
1,1-Dimethylbiguanide hydrochloride
Cas No: 1115-70-4
No Data 1 Kilogram 1 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
High quality 1, 1-Dimethyl-Biguanid Hydrochloride supplier in China
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No Data No Data No Data Simagchem Corporation Contact Supplier
Metformin hydrochloride
Cas No: 1115-70-4
USD $ 2.0-3.0 / Kilogram 1 Kilogram 1-10 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
1115-70-4 1,1-Dimethylbiguanide hydrochloride
Cas No: 1115-70-4
USD $ 1000.0-1000.0 / Kilogram 1 Kilogram 1 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier

1115-70-4 Usage

Oral hypoglycemic agents

Metformin hydrochloride is a biguanide oral hypoglycemic agent , also known as  Glucophage,  its hypoglycemic effect is weaker than phenformin, the main role is to reduce the glucagon secretion of A cells ,and to promote the conversion of glucose to glycogen, its characteristic effect including that it does not  stimulate pancreatic β-cells to secrete insulin .
The follows are hypoglycemic mechanisms:
1. Increasing the sensitivity of peripheral tissues to insulin, increase insulin-mediated glucose utilization.
2. Increasing glucose utilization of non-insulin-dependent tissues, such as brain, blood cells, kidney medulla, intestine, skin and so on.
3. Inhibiting hepatic gluconeogenesis effect , reducing hepatic glucose output.
4. Inhibiting glucose uptake by intestinal cells.
5. Inhibiting the biosynthesis and storage of cholesterol , lowering blood triglycerides and total cholesterol levels.
Metformin hydrochloride is clinically used for the treatment of type Ⅱ diabetes patients who are not satisfied with simple diet control, especially patients with obesity and hyperinsulinemia, usage of this drug not only displays no hypoglycemic effect, but also there may be weight loss and hyperinsulinemia effect. For some patients with poor efficacy of sulfonylurea ,it may be effective, if it is used with hypoglycemic drugs including sulfonylurea, intestinal glucosidase inhibitors or thiazolidinediones, the results are better than used alone. It can also be used in patients with insulin therapy to reduce the amount of insulin.
At present, domestic manufacturer mainly include the American Shanghai Squibb Pharmaceutical Co., Ltd .

Application

  • The product belongs to hypoglycemic agents. It can be used in patients with type Ⅱ diabetes to reduce fasting and postprandial hyperglycemia, HbAlc can be decreased by 1% to 2%, hypoglycemic mechanism of this product may be: I increase the sensitivity of peripheral tissues to insulin, increases insulin-mediated glucose utilization . II increase glucose utilization  of non-insulin dependent tissues, such as brain, blood cells, kidney medulla, intestine, skin and the like. III inhibit hepatic gluconeogenesis effect, reduce hepatic glucose output. IV inhibit  glucose uptake by intestinal cells.
  • Indications: For mild diabetes.
  • Metformin hydrochloride is an anti-diabetic agent, reducing blood glucose levels, and improving insulin sensitivity. Its metabolites (including the inhibition of hepatic gluconeogenesis) is activated through LKB1-AMPK (AMP-activated protein kinase)  path.
  • Hypoglycemic agents, it is used for non-insulin-dependent diabetes. Rat oral LD50 of 1000 mg/kg.

Chemical Properties

White crystal or crystalline powder. Melting point 232 ℃ (218-220 ℃). Soluble in water, dissolved in methanol, slightly soluble in ethanol, insoluble in ether and chloroform. Odorless, bitter taste.

Biological Activity

Antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines.

Production method

After the salifying of dimethylamine and the reaction with dicyandiamide , the product is derived.

Uses

Anti-diabetic and anti-cancer activity

Adverse effects and precautions

Biguanide oral hypoglycemic agents can increase glucose utilization of surrounding tissues and inhibit the intestinal absorption of glucose, and inhibit glycogen gluconeogenesis and hepatic glucose output,it is mainly applied to obesity, dyslipidemia, type II diabetes patients. It almost has no hypoglycemic effect for normal persons ,  2 to 3 hours after taking for diabetes patients ,glucose decreases significantly.
Commonly used oral hypoglycemic agents include phenformin and metformin hydrochloride.
The incidence of adverse effects of metformin hydrochloride is higher than tolbutamide , common gastrointestinal reactions are anorexia, nausea, vomiting, abdominal pain, diarrhea, occasional metallic taste in the mouth, bad breath, nausea, loss of appetite and diarrhea and other gastrointestinal reactions, sometimes  hypoglycemia  is visible  .
Since the biguanide drugs enhance sugar anaerobic glycolysis, and inhibit  glycogen generation, small number of patients may suffer with ketosis or lactic acidosis, which should be particularly vigilant, but metformin effect is weak  , adverse reactions are only  1/50 of other biguanides, and it has rapid clearance, there are no accumulation in the liver, it rarely induces lactic acidosis, sometimes there is mild increase in blood lactate. patients with heart, liver, kidney diseases are prone to these adverse reactions, diabetes patients with these types of complications are hanged. It can reduce the absorption of vitamin B12, but it seldom causes anemia. The following cases are contraindications:
1. Pregnant and lactating women, children under 10 years of age, 80 years of age or older.
2. Diabetic ketoacidosis, diabetic hyperglycemic hyperosmolar syndrome, diabetes lactic acidosis.
3. Severe liver and kidney dysfunction, blood urea nitrogen and creatinine higher than normal, hypovolemic shock, heart failure, AMI, in vivo hypoxic condition such as heart failure, pulmonary insufficiency, or any systemic hypoxia circumstances and other serious heart and lung diseases.
4. Severe infection or trauma, major surgery, clinical hypotension , hypoxia and so on.
5. Complications with severe diabetic nephropathy and retinopathy. When there are symptoms,the drug  should be immediately discontinued; cimetidine can reduce the renal excretion of metformin hydrochloride, agar types can reduce the absorption of metformin, patients must check liver and kidney function and cardiac ketones regularly.
6. Alcoholics, vitamin B12 and folate deficiency which are not corrected.

Chemical Properties

Crystalline Solid

Definition

ChEBI: A hydrochloride resulting from the reaction of metformin with one molar equivalent of hydrogen chloride.

Brand name

Fortamet (Andrx); Glucophage (Bristol-Myers Squibb); Glumetza (Depomed); Riomet(Ranbaxy).

Uses

An oral hypoglycemic agent
InChI:InChI=1/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H

1115-70-4 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (D150959)  1,1-Dimethylbiguanidehydrochloride  97% 1115-70-4 D150959-5G 964.08CNY Detail
Cerilliant (M-072)  Metforminhydrochloridesolution  1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material 1115-70-4 M-072-1ML 1,302.21CNY Detail
USP (1396309)  Metforminhydrochloride  United States Pharmacopeia (USP) Reference Standard 1115-70-4 1396309-200MG 5,477.94CNY Detail
Sigma-Aldrich (M0605000)  Metforminhydrochloride  European Pharmacopoeia (EP) Reference Standard 1115-70-4 M0605000 1,880.19CNY Detail
TCI America (M2009)  Metformin Hydrochloride  >98.0%(HPLC)(T) 1115-70-4 100g 2,620.00CNY Detail
TCI America (M2009)  Metformin Hydrochloride  >98.0%(HPLC)(T) 1115-70-4 25g 880.00CNY Detail

1115-70-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Metformin Hydrochloride

1.2 Other means of identification

Product number -
Other names N1,N1-Dimethylbiguanide hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1115-70-4 SDS

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