445006-98-4

Basic information

• Product Name: 3-(2-iodo-4,5-dimethoxyphenyl)-2,2-dimethylpropanenitrile
• Synonyms: 3-(2-iodo-4,5-dimethoxyphenyl)-2,2-dimethylpropanenitrile
• CAS NO: 445006-98-4
• Molecular Weight: 345.18
• Mol File: 445006-98-4.mol

Chemical Properties

• CAS DataBase Reference: 3-(2-iodo-4,5-dimethoxyphenyl)-2,2-dimethylpropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-iodo-4,5-dimethoxyphenyl)-2,2-dimethylpropanenitrile(445006-98-4)
• EPA Substance Registry System: 3-(2-iodo-4,5-dimethoxyphenyl)-2,2-dimethylpropanenitrile(445006-98-4)

Safety Data

• Hazardous Substances Data: 445006-98-4(Hazardous Substances Data)

Upstream product

• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 110451-87-1 2-bromomethyl-1-iodo-4,5-dimethoxybenzene 
• 78-82-0 Isobutyronitrile 
• 293732-19-1 (4,5-dimethoxy-2-iodophenyl)methyl bromide 

Downstream Products

• 149862-32-8 2,3-dihydro-5,6-dimethoxy-2,2-dimethylindan-1-one 

Relevant articles and documents

Carbopalladation of nitriles: Synthesis of benzocyclic ketones and cyclopentenones via Pd-catalyzed cyclization of ω-(2-iodoaryl)alkanenitriles and related compounds

An efficient procedure for the synthesis of 2,2-disubstituted benzocyclic ketones by intramolecular carbopalladation of nitriles has been developed. The cyclization of substituted 3-(2-iodoaryl)-propanenitriles affords indanones in high yields. The reaction is compatible with a wide variety of functional groups. This methodology has been extended to the synthesis of tetralones and cyclopentenones.