294178-41-9

Upstream product

• 294178-40-8 Acetic acid (2S,3R,4R,5R,6R)-3-benzyloxy-5-chloro-6-chloromethyl-2-methoxy-tetrahydro-pyran-4-yl ester 
• 20585-18-6 methyl 4,6-dideoxy-α-D-glucopyranoside 
• 108-24-7 acetic anhydride 
• 100-39-0 benzyl bromide 
• 4990-91-4 (2S,3R,4R,5S,6R)-5-chloro-6-(chloromethyl)-2-methoxytetrahydro-2H-pyran-3,4-diol 
• 97-30-3 methyl-alpha-D-glucopyranoside 
• 5088-33-5 Chlorosulfuric acid (2S,3R,4R,5R,6R)-5-chloro-6-chloromethyl-4-chlorosulfonyloxy-2-methoxy-tetrahydro-pyran-3-yl ester 
• 76375-66-1 methyl 2-O-benzyl-4,6-O-benzylidene-α-D-glucopyranoside 
• 99152-61-1 methyl 3-O-acetyl-2-O-benzyl-α-D-glucopyranoside 
• 99212-41-6 methyl 3-O-acetyl-2-O-benzyl-4,6-O-benzylidene-α-D-glucopyranoside 
• 3162-96-7 4,6-O-benzylidene-1-O-methyl-α-D-glucopyranoside 

Downstream Products

• 294178-45-3 Phosphoric acid (2R,3R,4S,6R)-4-azido-3-benzyloxy-6-methyl-tetrahydro-pyran-2-yl ester dibenzyl ester 
• 294178-43-1 (2S,3R,4S,6R)-4-Azido-3-benzyloxy-2-methoxy-6-methyl-tetrahydro-pyran 
• 294178-42-0 (2S,3R,4R,6R)-3-Benzyloxy-2-methoxy-6-methyl-tetrahydro-pyran-4-ol 
• 72212-12-5 (2S,3S,6R)-3-Benzyloxy-2-methoxy-6-methyl-tetrahydro-pyran-4-one 
• 451505-76-3 (2S,3R,4S,6R)-3-Benzyloxy-2-methoxy-6-methyl-tetrahydro-pyran-4-ol 

Relevant academic research and scientific papers

Synthesis of TDP-3-amino-3,4,6-trideoxy-α-D-xylo-hexopyranose - The immediate precursor of TDP-α-D-desosamine

A synthetic pathway producing the title compound starting from methyl α-D-glucose is described. This compound was shown to be a substrate for DesVI, an AdoMet-dependent methyltransferase which catalyzes N,N-dimethylation of the title compound to give a biological significant unusual sugar, desosamine.

DesVI: A new member of the sugar N,N-dimethyltransferase family involved in the biosynthesis of desosamine

Purification and characterization of a new enzyme belonging to the amino sugar N,N-dimethyltransferase family has been achieved. DesVI catalyzes the successive transfer of two methyl groups in the biosynthetic pathway of desosamine (see scheme), an unusua