21303-50-4

Usage

Uses

Used in Rubber Industry:
5-Methyl-2-mercaptobenzothiazole is used as a vulcanizing agent and preservative for enhancing the durability and resistance of rubber products. Its presence helps to prevent the degradation of rubber due to heat, oxygen, and microbial attack, thereby extending the lifespan of rubber goods.
Used in Industrial Water Systems:
In this application industry, 5-Methyl-2-mercaptobenzothiazole is used as a biocide to control the growth of bacteria, fungi, and other microorganisms that can cause biofouling, corrosion, and other issues in water systems. Its antimicrobial properties help maintain the efficiency and integrity of these systems.
Used in Oil and Gas Industry:
5-Methyl-2-mercaptobenzothiazole is used as a corrosion inhibitor to protect metal surfaces from the damaging effects of corrosive agents present in the oil and gas extraction and processing environments. Its application helps to reduce maintenance costs and extend the service life of equipment.
Used in Pesticide Production:
5-Methyl-2-mercaptobenzothiazole is used as an active ingredient in the manufacturing of pesticides, where it leverages its antimicrobial and antifungal properties to control pests and diseases in agricultural settings, thereby contributing to crop protection and yield enhancement.
Used in Pharmaceutical Development:
Although still in the exploratory stage, 5-Methyl-2-mercaptobenzothiazole has shown potential for use in pharmaceuticals. Its unique chemical structure and biological activity are being investigated for possible applications in the development of new drugs, particularly those targeting microbial infections or other therapeutic areas where its properties could be beneficial.

InChI:InChI=1/C8H7NS2/c1-5-2-3-7-6(4-5)9-8(10)11-7/h2-4H,1H3,(H,9,10)

Upstream product

• 89-60-1 1-chloro-4-methyl-2-nitro-benzene 
• 75-15-0 carbon disulfide 
• 452-84-6 3-amino-4-fluorotoluene 
• 53078-85-6 2-bromo-5-methylaniline 
• 108-44-1 1-amino-3-methylbenzene 
• 13194-69-9 2-iodo-5-methylaniline 
• 140-89-6 potassium ethyl xanthogenate 
• 638-03-9 m-toluidine hydrochloride 
• 95-81-8 2-chloro-5-methylaniline 

Downstream Products

• 3622-48-8 5-methyl-2-methylsulfanyl-1,3-benzothiazole 
• 80945-66-0 (5-methyl-1,3-benzothiazol-2-yl)hydrazine 
• 315228-94-5 1-[3-Chloro-2-(5-methyl-benzothiazol-2-ylsulfanyl)-5-nitro-phenyl]-ethanone 
• 2942-16-7 5-methylbenzo[d]thiazole 
• 3622-31-9 2-chloro-5-methylbenzo[d]thiazole 
• 14779-17-0 2-amino-5-methylbenzothiazole 

Relevant academic research and scientific papers

Thiazolyl and benzothiazolyl hydrazones derived from α-(N)-acetylpyridines and diazines: Synthesis, antiproliferative activity and CoMFA studies

The synthesis of a series of thiazolyl and benzothiazolyl hydrazones derived from α-(A3-acylpyridines, -quinolines, -isoquinolines, -pyridazines, -pyrimidines, and -pyrazines is reported. The stereochemistry of these compounds was determined by NMR spectroscopic methods. The antiproliferative activity of the novel compounds was quantified in tissue culture (melanoma, breast carcinoma, colon adenocarcinoma, epitheloid cervix carcinoma, Burkitt's lymphoma, leukemia, and hydroxyurea sensitive and resistant myelogenous leukemia sublines). All compounds exhibited profound antiproliferative activity, in particular against Burkitt's lymphoma cells. Out of this series, compounds 6b, 7b, 7c, 8c and 8i were found to be 13-900 times more potent than hydroxyurea and no cross-resistance to hydroxyurea was observed. A predictive 3D-QSAR model using the CoMFA approach was established.

Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2

Limited therapeutic options are available for the treatment of human schistosomiasis caused by the parasitic Schistosoma flatworm. The B cell lymphoma-2 (BCL-2)-regulated apoptotic cell death pathway in schistosomes was recently characterized and shown to share similarities with the intrinsic apoptosis pathway in humans. Here, we exploit structural differences in the human and schistosome BCL-2 (sBCL-2) pro-survival proteins toward a novel treatment strategy for schistosomiasis. The benzothiazole hydrazone scaffold previously employed to target human BCL-XL was repurposed as a starting point to target sBCL-2. We utilized X-ray structural data to inform optimization and then applied a scaffold-hop strategy to identify the 5-carboxamide thiazole hydrazone scaffold (43) with potent sBCL-2 activity (IC50 30 nM). Human BCL-XL potency (IC50 13 nM) was inadvertently preserved during the optimization process. The lead analogues from this study exhibit on-target activity in model fibroblast cell lines dependent on either sBCL-2 or human BCL-XL for survival. Further optimization of the thiazole hydrazone class is required to exhibit activity in schistosomes and enhance the potential of this strategy for treating schistosomiasis.

Synthesis and evaluation of some benzothiazole derivatives as antidiabetic agents

Objective: The objective of the present research investigation involves synthesis and biological evaluation of antidiabetic activity of benzothiazole derivatives. Methods: A novel series of benzothiazole derivatives 7(a-l) were synthesised and synthesised compounds were characterised for different physical and chemical properties like molecular formula, molecular weight, melting point, percentage yield, Rf value, IR,1HNMR,13CNMR and mass spectroscopy. The newly synthesised benzothiazole derivatives were subsequently assayed in vivo to investigate their hypoglycemic activity by the alloxan-induced diabetic model in rats. Results: All the synthesised derivatives showed significant biological efficacy. The compound 7d at 350 mg/kg exerted maximum glucose lowering effects whereas 7c showed minimum glucose lowering effects. All the compounds were effective, and experimental results were statistically significant at p0.01 and p0.05 level. Conclusion: From the results, it is clear that compound 7d demonstrated potent anti-diabetic activity and would be of better use in drug development to combat the metabolic disorder in future.

Efficient, Iron-Catalyzed Synthesis of 2-Mercaptobenzothiazole Through S-Arylation/Heterocyclization of 2-Haloaniline with Potassium Xanthate

A mild and practical method for the synthesis of 2-mercaptobenzothiazole has been developed by using iron as an efficient catalyst. The present tandem reaction process allows access to a wide range of 2-mercaptobenzothiazoles in good to excellent yields by the reaction of 2-haloaniline with potassium O-ethyl dithiocarbonate in the presence of FeF3 as a catalyst and 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl as a ligand under an atmosphere of argon.

COMPOUNDS FOR MODULATING TRPV3 FUNCTION

The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.

Therapeutic modulation of PPARgamma activity

Modulators of PPARγ activity are used in methods of treating and/or preventing conditions such as osteoporosis, Alzheimer's disease, psoriasis and acne, and cancer.

Compounds for the modulation of PPARgamma activity

Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.

Heterocyclic compounds

The invention provides compounds of formula (I) having nematicidal, insecticidal, acaricidal and fungicidal properties, compositions comprising them and processes and intermediates for their preparation: STR1 wherein: X is oxygen or sulphur; n is 0, 1 or 2; R1, R2, R3, and R4 are as described in the specification.

Selective herbicides

A selective herbicidal composition comprising an effective amount of a compound of the formula SPC1 Wherein R is selected from the group consisting of isopropyl and tertbutyl.