294204-40-3Relevant academic research and scientific papers
General and selective syn -carboxylation-trifluoromethylation of terminal alkynes: Application to the late-stage modification of dehydrocholic acid
Zhang, Song-Lin,Xiao, Chang,Wan, Hai-Xing,Zhang, Xiaoming
, p. 4099 - 4102 (2019)
A general and selective method is developed that allows difunctionalization of terminal alkynes by a Cu(iii)-CF3 complex and a carboxylic acid regioselectively and with unusual syn-stereochemistry. This method is broadly applicable to various carboxylic acids and terminal alkynes, producing a range of biologically active trifluoromethyl enol carboxylic esters. The synthetic potential of this method is further demonstrated by the late-stage functionalization of a complex pharmaceutical compound dehydrocholic acid.
