29428-84-0Relevant articles and documents
Synthesis of natural isocoumarins, artemidin and 3-propylisocoumarin
Batu,Stevenson
, p. 1532 - 1534 (1980)
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Synthesis of Side Chain Substituted 3-Butylisocoumarins and Absolute Configurations of Natural Isocoumarins from Artemisia dracunculus
Lutz-Kutschera, Gerda,Engelmeier, Doris,Hadacek, Franz,Werner, Andreas,Greger, Harald,Hofer, Otmar
, p. 1195 - 1206 (2007/10/03)
A series of 3-hydroxy- and 3-bromobutyl-substituted isocoumarins was synthesized. The absolute configurations of three isocoumarin derivatives from Artemisia dracunculus, namely (-)-epoxyartemidin, (-)-2′- methoxydihydroartemidin, and (+)-3′-hydroxyartemidin were determined by chemical means via derivatization, kinetic racemate resolution (Horeau method), and comparison of the circular dichroism (CD) spectra.
Synthesis of cis- and trans-Artemidins
Chatterjea, J. N.,Bhakta, C.,Mukherjee, Sanat K.
, p. 992 - 993 (2007/10/02)
Cis- and trans-artemidins (4) and (5) have been synthesised from 3-butanoylisocoumarin (1).Compound (1) on sodium borohydride reduction affords the alcohol (2) which is converted into the mesylate (3).The mesylate (3) on dehydration using 1,5-diazabicycloundecene-5 at room temperature in benzene furnishes a mixture of 4 and 5, which are separated by column chromatography over silica gel.