294862-91-2Relevant academic research and scientific papers
Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors
Terasaka, Tadashi,Okumura, Hiroyuki,Tsuji, Kiyoshi,Kato, Takeshi,Nakanishi, Isao,Kinoshita, Takayoshi,Kato, Yasuko,Kuno, Masako,Seki, Nobuo,Naoe, Yoshinori,Inoue, Takeshi,Tanaka, Kohichiro,Nakamura, Katsuya
, p. 2728 - 2731 (2004)
We disclose optimization efforts based on the novel non-nucleoside adenosine deaminase (ADA) inhibitor, 4 (Ki = 680 nM). Structure-based drug design utilizing the crystal structure of the 4/ADA complex led to discovery of 5 (Ki = 11
Heterocyclic compound, composition and method for inhibiting adenosine deaminase
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, (2008/06/13)
Heterocyclic compounds of the following formula: wherein B is ?[wherein R1is hydrogen or lower alkyl; R2is hydrogen or lower alkyl; and X is hydrogen or hydroxy protective group], lower alkanoyl or hydroxyimino(lower)alkyl A is lower
