294871-39-9Relevant academic research and scientific papers
Membrane-active antimicrobial poly(amino-modified alkyl) β-cyclodextrins synthesized: Via click reactions
Yamamura, Hatsuo,Nonaka, Miho,Okuno, Shingo,Mitsuhashi, Ryogo,Kato, Hisato,Katsu, Takashi,Masuda, Kazufumi,Tanimoto, Koichi,Tomita, Haruyoshi,Miyagawa, Atsushi
, p. 509 - 518 (2018)
The emergence of drug-resistant bacteria has led to the high demand for new antibiotics. In this report, we investigated membrane-active antimicrobial β-cyclodextrins. These contain seven amino-modified alkyl groups on a molecule, which act as functional
A reasonably stereospecific multistep conversion of Boc-protected α-amino acids to Phth-protected β3-amino acids
Temperini, Andrea,Capperucci, Antonella,Degl'Innocenti, Alessandro,Terlizzi, Raffaella,Tiecco, Marcello
supporting information; experimental part, p. 4121 - 4124 (2010/08/20)
A method for the synthesis of β3-amino acids starting from α-amino acids is described. This conversion can be effected by an eight-step procedure which involves the transformation of the carboxylic group into an alkyne followed by a selenium-mediated conversion of the carbon-carbon triple bond to a Se-phenyl selenocarboxylate intermediate. The reactive Se-phenyl selenocarboxylate intermediates can be trapped with water, alcohols or the amine of an amino acid derivative to give β3-amino acids, β3-amino esters or mixed peptides, respectively. The whole transformations of the carboxylic group into an alkyne and of the alkyne group into β3-amino acids may not require purification of the intermediate products but a work-up and isolation procedure of crude materials.
Compounds, compositions and methods for treatment of parasitic infections
-
, (2008/06/13)
Compounds and pharmaceutical compositions useful as anti-parasitic agents agents, particularly in the treatment, prevention or amelioration of one or more symptoms of malaria or Chagas' disease, are provided. In particular, methods of modulating the activ
