2951-10-2Relevant academic research and scientific papers
A novel one-step conversion of α,β-epoxy ketones to o-dichlorobenzaldehydes by the Vilsmeier reaction
Megati, Sreenivasulu,Rao, Krishna G. S.
, p. 5819 - 5822 (1995)
A novel, versatile one-step synthesis of o-dichlorobenzaldehydes has been developed. Acyclic α,β-epoxy ketones undergo the Vilsmeier reaction to afford o-dichlorobenzenemono- and dicarboxyaldehydes whereas cyclic α,β-epoxy ketones gave des and chlorobenzenedicarboxyaldehydes.
Vilsmeier reaction studies on some α,β-unsaturated alkenones
Sreenivasulu, M.,Rao, G. S. Krishna
, p. 494 - 495 (2007/10/02)
α,β-Unsaturated alkenones (1a-g) are converted into chlorobenzenemono-, di- and tricarboxaldehydes (2a-h) under Vilsmeier reaction conditions.Besides six known chlorobenzaldehydes the route affords, in a one-pot reaction, two new members of this class of compounds, 3-methyl-(2d) and 3,5-dimethyl-(2h)-2-chlorobenzaldehydes.
