29539-11-5

Upstream product

• 67219-44-7 (2-(bromomethyl)benzyl)triphenyl-1-phosphonium bromide 
• 91-13-4 α,α'-dibromo-o-xylene 
• 405198-79-0 {2-[2-(4-methoxyphenyl)ethynyl]phenyl}methanol 
• 176910-67-1 2-(4-methoxyphenylethynyl)benzaldehyde 
• 6630-33-7 ortho-bromobenzaldehyde 
• 768-60-5 4-methoxyphenylacetylen 

Relevant academic research and scientific papers

Cascade reaction of alkynols with 1-(2-aminophenyl)prop-2-ynols to form a fused 5,5,6-tricyclic system: Formation of four bonds in a single reaction

A novel cascade reaction of internal alkynols with 1-(2-aminophenyl)prop-2-ynols has been developed to form a new N,O-containing fused 5,5,6-tricyclic skeleton. Mechanistic studies indicate that this reaction proceeds via alkynol cycloisomerization, intermolecular substitution with 1-(2-aminophenyl)prop-2-ynols, and intermolecular addition with alkynols and consequent cyclizations. In this way, two C-C bonds, one C-O bond and one C-N bond form to give a tricyclic skeleton in a single reaction.

Synthesis of Functionalized 1H-Isochromene Derivatives via a Au-Catalyzed Domino Cycloisomerization/Reduction Approach

A Au-catalyzed versatile and efficient access to 1H-isochromenes is reported. The efficiency of the [AuCl2(Pic)] complex (1-5 mol %) was demonstrated and allowed a domino cycloisomerization/reduction reaction process starting from a wide range of functionalized ortho-alkynylbenzaldehydes and one example of ortho-alkynylpyridinylaldehyde. The smooth reaction conditions were amenable to aryl- and alkyl-substituted alkynyl derivatives, as well as functionalized halogen and ether moieties, leading to a chemo- and regioselective 6-endo-cyclization with good to excellent yields.

Synthesis of isocoumarin via PTSA-catalyzed annulation of diarylalkynes

p-Toluenesulfonic acid (PTSA) in ethanol was used as a mild acid catalyst for the annulation of various functionalized diarylalkynes under microwave irradiation. This metal-free process allowed the synthesis of a range of 3-aryl-substituted isocoumarins in good yields. Georg Thieme Verlag Stuttgart.