29582-39-6

Basic information

• Product Name: TRANS-3-(4-CHLOROBENZOYL)ACRYLIC ACID
• Synonyms: acide(e)4-(4-chlorophenyl)4-oxo2-butenoique;(E)-3-(4-Chlorobenzoyl)acrylic acid;(E)-4-Oxo-4-(4-chlorophenyl)-2-butenoic acid;trans-3-(4-Chlorobenzoyl)acrylic acid 97%;2-Butenoic acid,4-(4-chlorophenyl)-4-oxo-, (2E)-
• CAS NO: 29582-39-6
• Molecular Formula: C₁₀H₇ClO₃
• Molecular Weight: 210.61
• Product Categories: C10;Carbonyl Compounds;Carboxylic Acids;Building Blocks;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks
• Mol File: 29582-39-6.mol
• Article Data: 24

Chemical Properties

• Melting Point: 130-134 °C(lit.)
• Boiling Point: 379.5°Cat760mmHg
• Flash Point: 183.3°C
• Appearance: /
• Density: 1.366g/cm³
• PKA: 3.09±0.10(Predicted)
• CAS DataBase Reference: TRANS-3-(4-CHLOROBENZOYL)ACRYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: TRANS-3-(4-CHLOROBENZOYL)ACRYLIC ACID(29582-39-6)
• EPA Substance Registry System: TRANS-3-(4-CHLOROBENZOYL)ACRYLIC ACID(29582-39-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 29582-39-6(Hazardous Substances Data)

Usage

General Description

TRANS-3-(4-chlorobenzoyl)acrylic acid is a compound with a molecular formula C10H7ClO3. It is a derivative of acrylic acid and is a yellow to brown solid that is insoluble in water. This chemical is primarily used in the production of pharmaceuticals, agrochemicals, and as a reagent in organic synthesis. It has also been studied for its potential anti-inflammatory and antitumor properties. Additionally, this compound may also have applications as a building block in the synthesis of other organic compounds. Overall, TRANS-3-(4-chlorobenzoyl)acrylic acid has various industrial and scientific uses, making it a valuable chemical in the field of organic chemistry.

Upstream product

• 108-31-6 maleic anhydride 
• 108-90-7 chlorobenzene 
• 99-91-2 para-chloroacetophenone 
• 298-12-4 Glyoxilic acid 
• 89781-40-8 C₁₂H₁₁ClO₃ 
• 28587-05-5 3-dimethylamino-1(4-chloro-phenyl)-2-propen-1-one 
• 563-96-2 2,2-dihydroxyacetic acid 
• 1777-56-6 4-chlorobenzoylmethylenetriphenylphosphorane 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 2689-81-8 (4-chlorophenacyl)triphenylphosphonium bromide 

Downstream Products

• 3984-34-7 4-(4-chlorophenyl)-4-oxobutanoic acid 
• 924283-88-5 2-acetyl-3-[2-(4-chlorophenyl)-2-oxoethyl]succinic acid 1-ethyl ester 
• 57192-22-0 2-[2-(4-chlorophenyl)-2-oxoethyl]-3-phenylsuccinic acid 4-ethyl ester 
• 924283-93-2 2-[2-(4-chlorophenyl)-2-oxoethyl]-3,3-dicyanopropionic acid 
• 97220-72-9 2-acetylthio-3-(4-chlorobenzoyl)propionic acid 
• 89781-40-8 ethyl (E)-4-(4-chlorophenyl)-4-oxo-2-butenoate 
• 873572-00-0 C₁₉H₁₅ClN₄O₄S₂ 
• 898645-86-8 C₁₉H₁₅ClN₄O₄S₂ 
• 1116119-26-6 benzyl (E)-4-(4-chlorophenyl)-4-oxobut-2-enoate 
• 1334219-05-4 4-(4'-chlorophenyl)-4-oxo-2-((S)-1-phenylethylamino)butanoic acid 
• 32149-26-1 (E)-methyl 4-(4-chlorophenyl)-4-oxobut-2-enoate 
• 1160787-32-5 6-(4-chlorophenyl)-2-(4-(aminosulfonyl)phenyl)pyridazin-3(2H)-one 
• 85460-66-8 (E)-1-(4-chlorophenyl)-3-(4-(dimethylamino)phenyl)prop-2-en-1-one 
• 1606167-99-0 C₁₄H₁₁ClNO⁽¹⁺⁾*Br^(1-) 

Relevant articles and documents

Base-Promoted Annulative Difluoromethylenation of Enaminones with BrCF2CO2Et toward 2,2-Difluorinated 2,3-Dihydrofurans

A practical method for the synthesis of 2,2-difluorinated 2,3-dihydrofurans has been established via the [4 + 1] annulation of enaminones and BrCF2CO2Et with Na2CO3 promotion. This new protocol does not employ any transition metal reagent and enables the annulative difluoromethylation by the partial cleavage of the C═C double bond. In addition, the further treatment with hydrochloric acid in one pot leads to β-keto enoic acids (4-oxo-2-butenoic acids) via a formal enaminone C-N carboxylation.

Metal-free reduction of unsaturated carbonyls, quinones, and pyridinium salts with tetrahydroxydiboron/water

A series of unsaturated carbonyls, quinones, and pyridinium salts have been effectively reduced to the corresponding saturated carbonyls, dihydroxybenzenes, and hydropyridines in moderate to high yields with tetrahydroxydiboron/water as a mild, convenient, and metal-free reduction system. Deuterium-labeling experiments have revealed this protocol to be an exclusive transfer hydrogenation process from water. This journal is

Synthesis of chiral γ-lactones via a RuPHOX-Ru catalyzed asymmetric hydrogenation of aroylacrylic acids

An asymmetric hydrogenation of aroylacrylic acids catalyzed by RuPHOX-Ru catalyst has been developed, affording the corresponding chiral γ-lactones in high yields and with up to 93% ee. The methodology has the advantage of utilizing easily accessible substrates and has therefore expand the scope of the resulting chiral γ-lactones. Furthermore, high catalytic efficiency was achieved in that the reduction of both the C[dbnd]C and C[dbnd]O double bonds was achieved in one step. The current work provides an alternative and convenient pathway for the synthesis of a wide range of chiral γ-lactones.