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32149-26-1

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32149-26-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 32149-26-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,1,4 and 9 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 32149-26:
(7*3)+(6*2)+(5*1)+(4*4)+(3*9)+(2*2)+(1*6)=91
91 % 10 = 1
So 32149-26-1 is a valid CAS Registry Number.

32149-26-1Relevant articles and documents

Endogenous Enzymes Enable Antimicrobial Activity

Hetrick, Kenton J.,Aguilar Ramos, Miguel A.,Raines, Ronald T.

, p. 800 - 805 (2021)

In light of the continued threat of antimicrobial-resistant bacteria, new strategies to expand the repertoire of antimicrobial compounds are necessary. Prodrugs are an underexploited strategy in this effort. Here, we report on the enhanced antimicrobial activity of a prodrug toward bacteria having an enzyme capable of its activation. A screen led us to the sulfurol ester of the antibiotic trans-3-(4-chlorobenzoyl)acrylic acid. An endogenous esterase makes Mycolycibacterium smegmatis sensitive to this prodrug. Candidate esterases were identified, and their heterologous production made Escherichia coli sensitive to the ester prodrug. Taken together, these data suggest a new approach to the development of antimicrobial compounds that takes advantage of endogenous enzymatic activities to target specific bacteria.

Isothiourea-mediated one-pot synthesis of functionalized pyridines

Stark, Daniel G.,Morrill, Louis C.,Yeh, Pei-Pei,Slawin, Alexandra M. Z.,O'Riordan, Timothy J. C.,Smith, Andrew D.

supporting information, p. 11642 - 11646 (2013/11/06)

Acids to bases: The synthesis of 2,4,6-trisubstituted pyridines from (phenylthio)acetic acid and a range of α,β-unsaturated ketimines is reported. This process proceeds by intermolecular Michael addition/ lactamization, thiophenol elimination, and N- to O

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