29585-02-2

Upstream product

• 108-10-1 4-methyl-2-pentanone 
• 7732-18-5 water 
• 7726-95-6 bromine 

Downstream Products

• 69798-66-9 4-Methyl-1-phenylthio-2-pentanon 
• 80524-75-0 4-methyl-1-(2,4,6-trimethylbenzenesulfonyloxy)-2-pentanone 
• 91182-56-8 2-bromo-3-(methylamino)naphthalene-1,4-dione 
• 68290-70-0 2-(1-methylethyl)-5-(2-methylpropyl)pyrazine 
• 1048660-74-7 N-(4-methylpentan-2-one)-3-(benzyloxy)-2-methylpyridinate bromide 
• 1373121-38-0 C₂₂H₂₄N₂O₃ 
• 1373121-57-3 C₁₄H₁₉BrN₂O₂ 
• 27653-95-8 4-methyl-1-(triphenylphosphaneylidene)pentan-2-one 
• 1616877-54-3 4-methyl-1-(2-(methylthio)phenoxy)pentan-2-one 

Relevant academic research and scientific papers

Photochemical α-bromination of ketones using N-bromosuccinimide: a simple, mild and efficient method

Aromatic and aliphatic carbonyl compounds undergo facile bromination with N-bromosuccinimide under UV-vis irradiation to give the corresponding α-brominated ketones in good yields, at low temperatures (30 °C), without any catalyst, catalyst support or radical initiator and within a short time.

Imidazole [2, 1-b] thiazole derivative as well as preparation method and application thereof

The invention belongs to the field of chemical pharmaceuticals, and particularly relates to an imidazole [2, 1-b] thiazole derivative as well as a preparation method and an application thereof. The structure of the imidazole [2, 1-b] thiazole derivative i

Discovery of imidazo[2,1- b ]thiazole HCV NS4B inhibitors exhibiting synergistic effect with other direct-acting antiviral agents

The design, synthesis, and SAR studies of novel inhibitors of HCV NS4B based on the imidazo[2,1-b]thiazole scaffold were described. Optimization of potency with respect to genotype 1b resulted in the discovery of two potent leads 26f (EC50 = 16

Oxidative bromination of ketones using ammonium bromide and oxone

A highly efficient, environmentally safe and economic method for selective α-monobromination of aralkyl, cyclic, acyclic, 1,3-diketones and β-keto esters and α,α-dibromination of 1,3-diketones and β-keto esters without catalyst is reported using ammonium bromide as a bromine source and oxone as an oxidant. The reaction proceeds at ambient temperature and yields range from moderate to excellent. Bromination of unsymmetrical ketones takes place at the less substituted α-position predominantly. Aromatisation of tetralones is also carried out with this reagent system.

Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2

We report a series of inhibitors of secreted phospholipases A2 (sPLA2s) based on substituted indoles, 6,7-benzoindoles, and indolizines derived from LY315920, a well-known indole-based sPLA2 inhibitor. Using the human group X sPLA2 crystal structure, we prepared a highly potent and selective indole-based inhibitor of this enzyme. Also, we report human and mouse group IIA and IIE specific inhibitors and a substituted 6,7-benzoindole that inhibits nearly all human and mouse sPLA 2s in the low nanomolar range.

Halogenation of carbonyl compounds by an ionic liquid, [AcMIm]X, and Ceric Ammonium Nitrate (CAN)

An ionic liquid, acetylmethylimidazolium halide ([AcMIm]X), in combination with ceric ammonium nitrate promotes halogenations of a wide variety of ketones and 1,3-keto esters at the ?-position. The ionic liquid acts here as reagent as well as reaction medium, and thus the reaction does not require any organic solvent or conventional halogenating agent. The reaction is completely arrested when the radical quencher TEMPO is used. A plausible radical mechanism is also suggested. CSIRO 2007.

A simple and efficient method for α-bromination of carbonyl compounds using N-bromosuccinimide in the presence of silica-supported sodium hydrogen sulfate as a heterogeneous catalyst

α-Bromination of carbonyl compounds (cyclic and acyclic ketones, amides and β-ketoesters) has been achieved efficiently by treatment with N-bromosuccinimide (NBS) and catalyzed by silica-supported sodium hydrogen sulfate (NaHSO4?SiO2

SELECTIVE MONOBROMINATION OF KETONES BY BIS(DIMETHYLACETAMIDE)HYDROGEN TRIBROMIDE

A unified procedure for the α-monobromination of ketones by bis(dimethylacetamide)hydrogen tribromide in methanol is proposed.Methyl aryl ketones with donating and moderately accepting substituents in the ring readily enter into the reaction. 1-Bromo ketones are mostly formed during the bromination of methyl alkyl ketones.