59507-44-7

Basic information

• Product Name: Piperidine, 1-[(4-nitrophenyl)methyl]-
• Synonyms: 1-(4-nitrobenzyl)piperidine;1-[(4-NITROPHENYL)METHYL]-PIPERIDINE;Piperidine, 1-[(4-nitrophenyl)methyl]-
• CAS NO: 59507-44-7
• Molecular Formula: C₁₂H₁₆N₂O₂
• Molecular Weight: 220.27
• Mol File: 59507-44-7.mol
• Article Data: 42

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Piperidine, 1-[(4-nitrophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-[(4-nitrophenyl)methyl]-(59507-44-7)
• EPA Substance Registry System: Piperidine, 1-[(4-nitrophenyl)methyl]-(59507-44-7)

Safety Data

• Hazardous Substances Data: 59507-44-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 17, p. 219, 1976 DOI: 10.1016/0040-4039(76)80022-6

Upstream product

• 110-89-4 piperidine 
• 100-14-1 4-nitrobenzyl chloride 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 555-16-8 4-nitrobenzaldehdye 
• 122-04-3 4-nitro-benzoyl chloride 
• 20857-92-5 N-(p-nitrobenzoyl)azacyclohexane 
• 42766-39-2 potassium 2-(4-nitrophenyl)acetate 
• 2591-86-8 N-Formylpiperidine 
• 619-73-8 4-nitrobenzyl chloride 
• 4043-87-2 pipecolic Acid 
• 586-78-7 para-nitrophenyl bromide 

Downstream Products

• 1234202-02-8 N-(4-(piperidin-1-ylmethyl)phenyl)-1H-indole-3-carboxamide 
• 1234201-94-5 2-(1H-indol-3-yl)-N-(4-(piperidin-1-ylmethyl)phenyl)acetamide 
• 1234202-00-6 3-(1H-indol-3-yl)-N-(4-(piperidin-1-ylmethyl)phenyl)propanamide 
• 1234202-10-8 N-((1H-indol-3-yl)methyl)-4-(piperidin-1-ylmethyl)aniline 
• 1234202-07-3 N-(2-(1H-indol-3-yl)ethyl)-4-(piperidin-1-ylmethyl)aniline 
• 1234202-09-5 N-(3-(1H-indol-3-yl)propyl)-4-(morpholinomethyl)aniline 
• 1567327-12-1 2-(4-(piperidin-1-ylmethyl)phenyl)benzo[d][1,2]selenazol-3(2H)-one 
• 1567327-17-6 5,6-dimethoxy-2-(4-(piperidin-1-ylmethyl)phenyl)benzo[d][1,2]selenazol-3(2H)-one 
• 555-16-8 4-nitrobenzaldehdye 
• 856437-30-4 2-chloro-N-(4-piperidin-1-ylmethylphenyl)acetamide 
• 1235087-45-2 1-(4-nitrobenzyl)piperidin-2-one 
• 20857-92-5 N-(p-nitrobenzoyl)azacyclohexane 
• 263337-30-0 (Z)-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)amino]-methylidene}-1,3-dihydro-2H-indolin-2-one 
• 334949-22-3 (Z)-2-oxo-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester 

Relevant articles and documents

Chemoselective Reduction of Tertiary Amides by 1,3-Diphenyl disiloxane (DPDS)

A convenient procedure for the chemoselective reduction of tertiary amides at room temperature in the presence of air and moisture using 1,3-diphenyldisiloxane (DPDS) is developed. The reaction conditions tolerate a significant number of functional groups including esters, nitriles, secondary amides, carbamates, sulfoxides, sulfones, sulfonyl fluorides, halogens, aryl-nitro groups, and arylamines. The conditions reported are the mildest to date and utilize EtOAc, a preferred solvent given its excellent safety profile and lower environmental impact. The ease of setup and broad chemoselectivity make this method attractive for organic synthesis, and the results further demonstrate the utility of DPDS as a selective reducing agent.

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