29619-45-2

Usage

Uses

Used in Pharmaceutical Industry:
6,6'-DiMethoxy-2,2'-binaphthalene is used as a synthetic intermediate for the development of novel classes of non-steroidal substrate mimetics. These mimetics have potential applications as inhibitors of human CYP17, an enzyme involved in steroid hormone synthesis, which can be beneficial in treating hormone-dependent conditions.
Used in Anti-Inflammatory Applications:
6,6'-DiMethoxy-2,2'-binaphthalene is also an impurity of Nabumetone (N200500), a non-steroidal anti-inflammatory drug. In this context, it contributes to the anti-inflammatory properties of the drug, helping to reduce inflammation and alleviate pain associated with various conditions.

Upstream product

• 623-00-7 4-bromobenzenecarbonitrile 
• 5111-65-9 2-Bromo-6-methoxynaphthalene 
• 5408-86-6 2,3-dibromobutane 

Relevant academic research and scientific papers

NAPHTHALENE-CONTAINING POLYMERS AND METHODS OF MAKING THE SAME

The present disclosure relates to a dimer that includes a first hydroxyl-functionalized naphthalene group and a second hydroxyl-functionalized naphthalene group, where the first hydroxyl-functionalized naphthalene group and the second hydroxyl-functionalized naphthalene group are connected by a bridging group. The present disclosure also relates to a polymer synthesized using the dimer, as well as methods for synthesizing both the dimer and the polymer.

Synthese und fluessigkristalline Eigenschaften 2,6-disubstituierter Naphtaline

The syntheses and the mesomorphic properties of a series of novel 2,6-disubstituted naphthalenes are described. 4-benzonitriles 5 and 4-benzonitriles 8 exhibit wide-range nematic mesophases. 6,6'-Di(n-Alkyl)-2,2'-binaphthyls 6 have been isolated as by-products from the reaction mixtures of 5.Some of these novel compounds have polymorphic properties.The esters 13 and 15 of 4-(6-hydroxy-2-naphthyl)benzonitrile show enhanced mesophase stabilities which reach maximum values in the series of α,β-unsaturated esters 15.The 4-(n-pentyl)benzoate 14 of the same (hydroxynaphthyl)benzonitrile has a melting point of 125 deg and a clearing point of > 310 deg.This particular derivative belongs to those liquid-crystalline compounds having the broadest purely nematic-phase range.In addition, (RS)-4-(2-pentyl-6-chromanyl)benzonitrile (20) and three compounds with two and four laterally arranged CN groups at the bicyclooctene, bicyclooctadiene, and phenyl-ring systems 31-33 were synthesized.Only 20 shows mesomorphic properties.