296242-28-9Relevant academic research and scientific papers
Synthesis of bioactive natural products by asymmetric syn-and anti-aldol reactions
Ghosh, Arun K.,Dawson, Zachary L.
scheme or table, p. 2992 - 3002 (2010/04/02)
The use of several variants of the asymmetric aldol reaction as key steps in the syntheses of bioactive target molecules is described. Georg Thieme Verlag Stuttgart.
Asymmetric synthesis of (-)-tetrahydrolipstatin: an anti-aldol-based strategy.
Ghosh,Fidanze
, p. 2405 - 2407 (2007/10/03)
A stereoselective synthesis of (-)-tetrahydrolipstatin is described. The synthesis involves an asymmetric ester derived titanium enolate anti-aldol reaction, a nitro-aldol reaction to append the C-2' C(11) side chain, and a diastereoselective reduction of a beta-hydroxy ketone to an anti-1,3-diol functionality followed by its elaboration to (-)-tetrahydrolipstatin.
