296242-40-5

Upstream product

• 296242-28-9 (S)-2-((E)-(S)-1-Hydroxy-3-phenyl-allyl)-octanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)-indan-2-yl ester 
• 296242-29-0 Octanoic acid (1S,2R)-1-(toluene-4-sulfonylamino)-indan-2-yl ester 
• 111-64-8 n-octanoic acid chloride 
• 14371-10-9 (E)-3-phenylpropenal 

Relevant academic research and scientific papers

Asymmetric synthesis of (-)-tetrahydrolipstatin: an anti-aldol-based strategy.

A stereoselective synthesis of (-)-tetrahydrolipstatin is described. The synthesis involves an asymmetric ester derived titanium enolate anti-aldol reaction, a nitro-aldol reaction to append the C-2' C(11) side chain, and a diastereoselective reduction of a beta-hydroxy ketone to an anti-1,3-diol functionality followed by its elaboration to (-)-tetrahydrolipstatin.