296274-10-7

Upstream product

• 141-97-9 ethyl acetoacetate 
• 459-57-4 4-fluorobenzaldehyde 
• 126-81-8 dimedone 
• 105-53-3 diethyl malonate 
• 626-34-6 ethyl aminocrotonate 
• 337513-52-7 2,2’?((4?fluorophenyl) methylene) bis (3?hydroxy?5,5?dimethylcyclohex?2?en?1?one) 

Downstream Products

• 1403364-10-2 C₂₁H₂₄FNO₃ 
• 1403364-09-9 C₂₁H₂₄FNO₃ 

Relevant academic research and scientific papers

Efficient one-pot synthesis of polyhydroquinoline derivatives through the Hantzsch condensation using IRMOF-3 as heterogeneous and reusable catalyst

A mesoporous Zn-based 2-amino terephthalate metal organic framework (IRMOF-3) catalyst was prepared using the solvothermal method. The synthesized catalyst was characterized by powder X-ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier tran

Sulfonamide-functionalized covalent organic framework (COF-SO3H): an efficient heterogeneous acidic catalyst for the one-pot preparation of polyhydroquinoline and 1,4-dihydropyridine derivatives

Herein, we report the sulfonamide-functionalized covalent organic framework (COF-SO3H) prepared from melamine and terephthalaldehyde and subsequent sulfonation, as an acidic porous catalyst for the one-pot preparation of polyhydroquinoline and

Biogenic synthesis of ZnO nanoparticles from Parthenium histerophorus extract and its catalytic activity for building bioactive polyhydroquinolines

Abstract: In the present protocol, biogenic synthesis of ZnO nanoparticles using an aqueous extract of weed, i.e. Parthenium is efficiently carried out. The proficient and operationally simple catalytic application of biogenic ZnO nanoparticle is explored towards a synthesis of pharmaceutically relevant and densely functionalized polyhydroquinolines by condensation of four components viz. aromatic aldehyde, dimedone, ethyl acetoacetate, and ammonium acetate. The synthesized polyhydroquinolines were screened for their antimicrobial activity against bacteria and fungi; some of them exhibit better to excellent activity. The developed protocol is enriched with captivating advantages such as excellent yields, shorter reaction time, recyclable catalyst and constructive use of an aqueous extract of Parthenium for the synthesis of ZnO nanoparticle. Graphical abstract: [Figure not available: see fulltext.]

Synthesis of MCM-41 supported cobalt (II) complex for the formation of polyhydroquinoline derivatives

A new and green heterogeneous MCM-41@PDCA-Co catalyst has been prepared via immobilization of cobalt (II) complex onto the surface of MCM-41. This was characterized by different techniques such as FT-IR, TEM, TGA, low angle Powder XRD, MP-AES and nitrogen

Preparation, Antibacterial Activity, and Catalytic Application of Magnetic Graphene Oxide-Fucoidan in the Synthesis of 1,4-Dihydropyridines and Polyhydroquinolines

Polymer-coated magnetic nanoparticles are emerging as a useful tool for a variety of applications, including catalysis. In the present study, fucoidan-coated magnetic graphene oxide was synthesized using a natural sulfated polysaccharide. The prepared BaF

Synthesis and Characterization of Magnetic Functionalized Ni and Cu Nano Catalysts and Their Application in Oxidation, Oxidative Coupling and Various Multi-Component Reactions

Abstract: Two magnetic nano catalysts of nickel and copper, Fe3O4@SiO2@DOP-BenPyr-M(II), (M=Ni and Cu) have been synthesized. These catalysts were applied as recoverable, efficient and new heterogeneous catalysts for the high yielding and room temperature one-pot procedure of selective oxidation of sulfides to sulfoxides and oxidative coupling of thiols to disulfides. In addition, the catalytic activity of Fe3O4@SiO2@DOP-BenPyr-Ni(II) was investigated as heterogeneous nanocatalyst for synthesis of 2,3-dihydroquinazolin-4(1H)-ones, 5-substituted 1H-tetrazoles and polyhydroquinolines. The synthesized catalysts were characterized by FT-IR, TGA, XRD, VSM, EDX, ICP and SEM techniques. These catalysts were recovered by an external magnet and reused several times without significant loss of catalytic efficiency. Graphic Abstract: [Figure not available: see fulltext.]

Synthesis of sulfonated melamine-functionalized Fe3O4@SiO2@Si–(CH2)3@melamine nanoparticles and its application in the synthesis of 4,4’-(aryl methylene)bis(3-methyl-1H-pyrazol-5-ol)s and hexahydroqui

In this work, sulfonated melamine-functionalized Fe3O4@SiO2@Si-(CH2)3@melamine nanoparticles were prepared through a simple approach and characterized by energy dispersive X-ray analysis (EDX), field

One-pot three-component synthesis of 1-amidoalkyl naphthols and polyhydroquinolines using a deep eutectic solvent: a green method and mechanistic insight

The multicomponent synthesis of 1-amidoalkyl naphthols and polyhydroquinolines has been developed as an atom-economic procedure catalyzed by a deep eutectic solvent ([CholineCl][ZnCl2]3). The reactions proceed smoothly at low temperatures for a short reaction time without the use of toxic and volatile organic solvents. Deep eutectic solvents are capable of not only allowing multicomponent reactions to proceed in high yield but also controlling the selectivity towards desired products. The mechanistic insight was examined by HRMS (ESI) to propose a plausible mechanism. Furthermore, [CholineCl][ZnCl2]3can be recycled in up to three consecutive cycles with an insignificant loss of catalytic activity under the optimized conditions.

New Copper Complex on Fe3O4 Nanoparticles as a Highly Efficient Reusable Nanocatalyst for Synthesis of Polyhydroquinolines in Water

Abstract: In this work, we present a simple, environmentally friendly and economical route for the preparation of a novel copper-Schiff-base organometallic complex on Fe3O4 nanoparticles (Fe3O4@Schiff-base-Cu) u

Synthesis of polyhydroquinolines and propargylamines through one-pot multicomponent reactions using an acidic ionic liquid immobilized onto magnetic Fe3O4as an efficient heterogeneous catalyst under solvent-free sonication

A nano-sized Fe3O4-supported Lewis acid ionic liquid catalyst for the synthesis of polyhydroquinolines and propargylamines under ultrasound irradiation has been developed. LAIL&at;MNP was synthesized from imidazolium chlorozincate(ii) ionic liquid grafted onto the surface of Fe3O4 nanoparticles and evaluated by FT-IR, TGA, SEM, Raman, TEM, ICP-OES, and EDS. The multicomponent synthesis of polyhydroquinolines and propargylamines proceeded smoothly to afford the desired products in high yields. LAIL&at;MNP can be separated easily from the reaction mixture and reused for several runs without a significant degradation in catalytic activity.