29638-51-5Relevant articles and documents
Highly Regioselective Synthesis of 3,6-Disubstituted 2-(Methylsulfanyl)pyrimidin-4(3 H)-ones
Dos Santos, Josiane M.,Da Silveira, Alessandra S.,Souza, Laura A.,Lobo, Marcio M.,Bonacorso, Helio G.,Martins, Marcos A. P.,Zanatta, Nilo
, p. 3947 - 3955 (2015/12/18)
This study reports a simple and highly regioselective synthesis of a new series of 3,6-disubstituted 2-(methylsulfanyl)pyrimidin-4(3H)-ones, in which the 6-substituents are methyl or aryl groups and the 3-substituents are alkyl, allyl, phenyl, benzyl, or 2-phenylethyl groups. The products are obtained in good yields by cyclocondensation of the appropriate 4-substituted 4-methoxy-1,1,1-trichloroalk-3-en-2-ones with nonsymmetric 1-substituted 2-methylisothiourea sulfates under mild basic conditions.
Synthesis and Biological Activity of 2,6-disubstituted 3-Aryl-4(3H)-pyrimidones as Potential CNS Agents
Gupta, K. A.,Saxena, Anil K.,Jain, Padam C.,Dua, P. R.,Prasad, C. R.,Anand, Nitya
, p. 789 - 794 (2007/10/02)
The reaction of N-arylamidines (III) with appropriate 2-alkynoic ester gives 2,6-disubstituted 3-aryl-4(3H)-pyrimidones (IV) in one step except in the reaction of N-(2-trifluoromethylphenyl/biphenyl)-S-methylisothiourea with ethyl propiolate, where the required pyrimidones (IVa17/IVa20) along with the adduct (Va/Vb) have been isolated; these adducts on cyclisation yield the corresponding pyrimidinones (IVa17/IVa20). 2,3,6-Triphenyl-4(3H)-pyrimidone (IVh1) on treatment with P2S5 furnishes the corresponding thione (VI).Some of these compounds have shown significant central muscle relaxant, hypnotic, anticonvulsant, CNS depressant, antiinflammatory and diuretic activities.
