68339-82-2Relevant academic research and scientific papers
Highly Regioselective Synthesis of 3,6-Disubstituted 2-(Methylsulfanyl)pyrimidin-4(3 H)-ones
Dos Santos, Josiane M.,Da Silveira, Alessandra S.,Souza, Laura A.,Lobo, Marcio M.,Bonacorso, Helio G.,Martins, Marcos A. P.,Zanatta, Nilo
, p. 3947 - 3955 (2015)
This study reports a simple and highly regioselective synthesis of a new series of 3,6-disubstituted 2-(methylsulfanyl)pyrimidin-4(3H)-ones, in which the 6-substituents are methyl or aryl groups and the 3-substituents are alkyl, allyl, phenyl, benzyl, or 2-phenylethyl groups. The products are obtained in good yields by cyclocondensation of the appropriate 4-substituted 4-methoxy-1,1,1-trichloroalk-3-en-2-ones with nonsymmetric 1-substituted 2-methylisothiourea sulfates under mild basic conditions.
