2965-17-5

Basic information

• Product Name: (2-fluorophenoxy)acetyl chloride
• Synonyms: (2-fluorophenoxy)acetyl chloride;acetyl chloride, (2-fluorophenoxy)-;2-(2-fluorophenoxy)acetyl chloride;2-(2-fluorophenoxy)ethanoyl chloride
• CAS NO: 2965-17-5
• Molecular Formula: C₈H₆ClFO₂
• Molecular Weight: 188.5834432
• Mol File: 2965-17-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 140-140.5 °C
• Boiling Point: 150-155 °C(Press: 70-75 Torr)
• Appearance: /
• Density: 1.321±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (2-fluorophenoxy)acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2-fluorophenoxy)acetyl chloride(2965-17-5)
• EPA Substance Registry System: (2-fluorophenoxy)acetyl chloride(2965-17-5)

Safety Data

• Hazardous Substances Data: 2965-17-5(Hazardous Substances Data)

Usage

General Description

"(2-fluorophenoxy)acetyl chloride" is a chemical compound composed of a benzene ring with a fluorine atom and an acetyl chloride group attached. It is a colorless, volatile liquid with a pungent odor and is commonly used as an intermediate in the production of pharmaceuticals, pesticides, and various organic compounds. (2-fluorophenoxy)acetyl chloride is reactive and has potential health hazards, and proper precautions should be taken when handling it. It is also important to store and use (2-fluorophenoxy)acetyl chloride in a well-ventilated area and with appropriate safety equipment to prevent harm to human health and the environment.

Upstream product

• 367-12-4 2-fluorophenol 
• 79-11-8 chloroacetic acid 
• 2248-56-8 ethyl 2-(4-fluorophenoxy)acetate 
• 348-10-7 (2-fluorophenoxy)acetic acid 

Downstream Products

• 904702-68-7 O-methyl [(2-(2-fluorophenoxy)acetoxy)(2-chlorophenyl)methyl]methylphosphinate 
• 904702-69-8 O-methyl [(2-(2-fluorophenoxy)acetoxy)(4-fluorophenyl)methyl]methylphosphinate 
• 1395103-28-2 2-(2-fluorophenoxyacetoxy)(phenyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 1395103-23-7 2-[(2-fluorophenoxy)acetoxy](furan-2-yl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 866146-00-1 O,O-dimethyl α-(2-fluorophenoxyacetoxy)ethylphosphonate 
• 904702-63-2 C₁₆H₁₇FNO₅P 
• 1031434-74-8 C₂₃H₁₉FN₂O₃ 

Relevant articles and documents

Herbicidal activity and application cyclic of phosphonates

Among alkylphosphonates Io,O,O-dimethyl 1-(2,4-dichlorophenoxyacetoxy) ethylphosphonate (clacyfos) was found to be an effective inhibitor against dicotyledons PHDc and exhibited excellent herbicidal activity in our previous work. According to our study on the alkylphosphonates Io, both R1 and R2 groups in the structural unit of phosphorus-containing played a very important role in herbicidal activity. Therefore, a series of 2-[1-(substituted phenoxycarboxy)alkyl]-5,5-dimethyl-1,3,2-dioxaphosphinane-2-one containing fluorine II was obtained by the modification of alkylphosphonates Io. The bioassay results showed that cyclic phosphonate II-6 with CH3 as R, 2-Cl,4-F as Yn exhibited promising herbicidal activity. Its herbicidal activity, weed-controlling spectrum, selectivity between crops and weeds were further evaluated in greenhouse and field.

Privileged 1,2,4-oxadiazoles in anticancer drug design: Novel 5-aryloxymethyl-1,2,4-oxadiazole leads for prostate cancer therapy

Based on the structure of the previously identified leads, new series of compounds containing 1,2,4-oxadiazole core was designed. A small, diverse library of 51 compounds including both 2-(acylamino)ethyl and 2-ureidoethyl side chains was synthesized using parallel chemistry and tested for antiproliferative activity against prostate cancer DU-145 cell line. Four hit compounds - all belonging to 2-ureidoethyl series - were identified and three compounds were confirmed as 10-20 μM inhibitors. The similarity in compounds' periphery and the data obtained previously suggest a similar mode of action for these compounds which was postulated as tubulin inhibition and was confirmed by in silico docking. These data provide further evidence for the privileged character of 1,2,4-oxadiazoles in antiproliferative compound design.

Synthesis and Herbicidal Activities of Sodium Methyl(α-(Substituted Phenoxyacetoxy)Alkyl)Phosphinates

A series of sodium methyl(α-(substituted phenoxyacetoxy)alkyl)phosphinates was designed and synthesized. Their structures were confirmed by IR, 1H NMR and elemental analysis, and some of them were further confirmed by MS. The results of bioassay showed that most of title compounds exhibited moderate to good herbicidal activities against the root of barnyard grass and rape at 10～100 mg/L.