348-10-7

Basic information

• Product Name: 2-FLUOROPHENOXYACETIC ACID
• Synonyms: 2-(o-Fluorophenoxy)acetic acid;(2-fluorophenoxy)acetic acid(SALTDATA: FREE);2-(2-Fluorophenoxy)acetic acid;(2-Fluorophenyloxy)acetic acid;2-(2-fluorophenoxy)ethanoic acid
• CAS NO: 348-10-7
• Molecular Formula: C₈H₇FO₃
• Molecular Weight: 170.14
• Mol File: 348-10-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 139 °C(Solv: benzene (71-43-2))
• Boiling Point: 289.2°Cat760mmHg
• Flash Point: 128.7°C
• Appearance: /
• Density: 1.321g/cm³
• Vapor Pressure: 0.00103mmHg at 25°C
• Refractive Index: 1.519
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.10±0.10(Predicted)
• CAS DataBase Reference: 2-FLUOROPHENOXYACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUOROPHENOXYACETIC ACID(348-10-7)
• EPA Substance Registry System: 2-FLUOROPHENOXYACETIC ACID(348-10-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 348-10-7(Hazardous Substances Data)

Usage

General Description

2-Fluorophenoxyacetic acid, also known as 2-Fluoro-4-phenoxyacetic acid, is a synthetic organic compound that belongs to the class of phenoxyacetic acids. It is a white crystalline solid that is soluble in water and commonly used as a herbicide. This chemical is known for its ability to control weeds by interrupting their growth and is commonly used in agricultural and horticultural practices. However, it is also a potential environmental hazard and may cause harm to aquatic organisms if not used properly. Additionally, it is important to handle this chemical with care and follow all safety guidelines when using it.

InChI:InChI=1/C8H7FO3/c9-6-3-1-2-4-7(6)12-5-8(10)11/h1-4H,5H2,(H,10,11)

Upstream product

• 367-12-4 2-fluorophenol 
• 79-11-8 chloroacetic acid 
• 2248-56-8 ethyl 2-(4-fluorophenoxy)acetate 
• 32376-32-2 2-fluorophenolate anion 

Downstream Products

• 399-45-1 2-(2-fluoro-4-nitrophenoxy)acetic acid 
• 2923-59-3 (2-fluoro-4,6-dinitro-phenoxy)-acetic acid 
• 2965-17-5 <2-Fluor-phenoxy>-acetylchlorid 
• 1063738-02-2 C₁₀H₁₀FNO₂ 
• 406928-41-4 2-(2-fluorophenoxy)-N-(3-pyridyl)acetamide 
• 904702-74-5 O-methyl [(2-(2-fluorophenoxy)acetoxy)(2,4-dichlorophenyl)methyl]methylphosphinate 
• 904702-72-3 O-methyl [(2-(2-fluorophenoxy)acetoxy)(phenyl)methyl]methylphosphinate 
• 904702-71-2 O-methyl [(2-(2-fluorophenoxy)acetoxy)(4-methylphenyl)methyl]methylphosphinate 
• 904702-69-8 O-methyl [(2-(2-fluorophenoxy)acetoxy)(4-fluorophenyl)methyl]methylphosphinate 

Relevant articles and documents

Synthesis and Biological Activity of Ethyl 4-Alkyl-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylate

(Chemical Equation Presented) A series of novel ethyl 4-(methyl or trifluoromethyl)-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylates 7a, 7b, 7c, 7d, 7e and 8f, 8g, 8h, 8i, 8j, 8k, 8l, 8m, 8n, 8o, 8p, 8q, 8r were synthesized, and their structures were confirmed by IR, 1H-NMR, MS spectra and elemental analysis. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal activities. Compared with the fluorine free compounds 7a, 7b, and 7e, the compounds bearing fluorine 8g, 8j, and 8q showed higher herbicidal activities with 70-100% inhibition against Capsella bursa-pastoris, Amaranthus restroflexus, and Eclipta prostrata at the dosage of 150 g/ha, which indicated that the trifluoromethyl on the thiazole ring was beneficial for the herbicidal activity. Furthermore, compounds 8f, 8g, 8h, 8i, 8j, 8k, 8l, 8m, 8n, 8o, 8p, 8q, 8r were tested for fungicidal activity against Pseudoperonospora cubensis at 500 μg/mL. Compounds 8f and 8q showed the best fungicidal activity with more than 80% inhibition.

Synthesis and biological activity of 1-(Substituted phenoxyacetoxy)- 1-(pyridin-2-yl or thien-2-yl)methylphosphonates

A series of novel O,O-dimethyl 1-(substituted phenoxyacetoxy)-1-(pyridin-2-yl or thien-2-yl)methylphosphonates 6a-n and 7a-d were synthesized. Their structures were confirmed by IR, 1H NMR, mass spectroscopy, and elemental analyses. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal and fungicidal activities. For example, the title compounds 6a, 6c, 6l, 6m, and 7d possess 90-100% inhibition against most of the tested plants at the dosage of 1500 g ai/ha, whereas the title compounds 6b, 6g-h and 6n possess 92-100% inhibition against Fusarium oxysporum, Phyricularia grisea, Botrytis cinereapers, Gibberella zeae, Sclerotinia sclerotiorum, and Cercospora beticola at the concentration of 50mg/L.

Synthesis and herbicidal activity of 2-(substituted phenoxyacetoxy)alkyl-5, 5-dimethyl-1,3,2-dioxaphosphinan-2-one containing fluorine

A series of novel 2-(substituted phenoxyacetoxy)alkyl-5,5-dimethyl-1,3,2- dioxaphosphinan-2-one bearing fluorine 5a-n and fluorine free 5o-q were designed and synthesized. The results of bioassay showed that some of the target compounds exhibited excellent herbicidal activities to Abutilon theophrasti, Brassica juncea, Amaranthus retroflexus and Eclipta prostrata in post-emergence treatment at a dosage of 150 g ai/ha. It could be found that the type and position of fluorine-containing group as X or Y on benzene ring had a very important effect on herbicidal activity. Compound 5l 2-[(2-chloro-4- fluorophenoxy)acetoxy](methyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one showed notable herbicidal activity, with 100% inhibition against A. theophrasti and A. retroflexus; and compound 5m 2-(3-trifluoromethylphenoxyacetoxy)(methyl) methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one with 100% inhibition against A. theophrasti even at a dosage of 75 g ai/ha. Additional crop selectivity testing showed that compounds 5g 2-(3-trifluoromethylphenoxyacetoxy)(phenyl)methyl-5,5- dimethyl-1,3,2-dioxaphosphinan-2-one and 5l are safe to rice, corn, cotton, rape and wheat.