2967-87-5Relevant academic research and scientific papers
Synthesis of α-Fluoroketones from Vinyl Azides and Mechanism Interrogation
Wu, Shu-Wei,Liu, Feng
supporting information, p. 3642 - 3645 (2016/08/16)
An efficient and mild fluorination of vinyl azides for the synthesis of α-fluoroketones is described. The mechanistic studies indicated that a single-electron transfer (SET) and a subsequent fluorine atom transfer process could be involved in the reaction.
A Practical Synthesis of α-Fluoroketones in Aqueous Media by Decarboxylative Fluorination of β-Ketoacids
Li, Jian,Li, Yin-Long,Jin, Nan,Ma, Ai-Lun,Huang, Ya-Nan,Deng, Jun
supporting information, p. 2474 - 2478 (2015/08/18)
A practical and novel process for the decarboxylative fluorination of β-ketoacids in water in the presence of phase transfer catalyst has been developed, affording a series of α-fluoroketones in good to excellent yields. Furthermore, a preliminary investigation for the catalytic asymmetric transformation was performed and a proposed mechanistic pathway for this catalytic process was proposed.
Metal-free, efficient oxyfluorination of olefins for the synthesis of α-fluoroketones
Yang, Qiang,Mao, Liu-Liang,Yang, Bin,Yang, Shang-Dong
supporting information, p. 3460 - 3463 (2014/07/21)
A novel oxyfluorination of olefin reactions has been developed. The reactions involve a metal-free and green catalytic system for the synthesis of α-fluoroketones which is an important building block for organic synthesis. Moreover, this reaction system exhibits great functional group tolerance.
Solvent directing immediate fluorination of aromatic ketones using 1- fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)
Stavber, Stojan,Jereb, Marjan,Zupan, Marko
, p. 1323 - 1324 (2007/10/03)
Reactions of aryl alkyl ketones with 1-fluoro-4-hydroxy1,4- diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Accufluor(TM) NFTh) in methanol result in selective and almost quantitative formation of the corresponding α-fluoroketones, while in acetonitrile exclusive fluorofunctionalisation of the activated aromatic ring take place.
