29670-53-9Relevant articles and documents
Material with long-service-life room-temperature phosphorescence phenomenon, preparation method and application
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Paragraph 0029-0031, (2019/06/07)
The invention discloses a material with a long-service-life room-temperature phosphorescence phenomenon, a preparation method and application. The material is prepared from an organic compound takingindolo-indole or indolocarbazole as a basic unit, wherein the organic compound has a structural general formula of a general formula I shown in the description, wherein Ar is an aromatic group or a derivative group thereof; R is a hydrogen atom or an alkyl chain, an olefin chain and a derivative group which contain 1-18 carbon atoms; and an R' position is a hydrogen atom or does not contain atoms.According to the material, the defects that an inorganic long afterglow material is difficult to synthesize and heavy metal elements need to be doped are overcome, and the material disclosed by the invention has the long-service-life room-temperature phosphorescence phenomenon.
Towards breast cancer targeting: Synthesis of tetrahydroindolocarbazoles, antibreast cancer evaluation, uPA inhibition, molecular genetic and molecular modelling studies
Ahmed, Entesar M.,Sarhan, Alaadin E.,El-Naggar, Dina H.,Khattab, Reham R.,El-Naggar, Mohamed,El-Messery, Shahenda M.,Hassan, Ghada S.,Mounier, Marwa M.,Mahmoud, Khaled,Ali, Neama I.,Mahrous, Karima F.,Ali, Mamdouh M.,El Sayed, Mardia T.
, (2019/10/08)
A series of some new tetrahydroindolocarbazole derivatives has been synthesized. The structure of the synthesized compounds has been confirmed by different spectroscopic techniques such as IR, NMR, elemental analysis and mass spectrometry. The target compounds were evaluated for their antitumor activity against breast cancer cell line MCF-7, their GI% and their LC50 have been determined. Six of the synthesized compounds exhibited GI% values against MCF-7 cell lines exceeding 70% ranging from 71.9 to 85.0% in addition that compound 11 expressed GI% values of 99.9% and considered the most active derivatives among the synthesized ones. Compound 11 showed a remarkable decrease of u PA level to 3.5 ng/ml compared to DOX. Compound 5, 11 and 15 showed significant decrease in expression of MTAP and CDKN2A, in addition to a remarkable decrease in DNA damage comet assay method. Molecular modeling studies were performed to interpretate the behavior of active ligands as uPA inhibitors.
An improved protocol for the preparation of 5, 11-dialkyl-6, 12-di(hetero)aryl-5, 11-dihydroindolo[3, 2-b]carbazoles and synthesis of their new 2, 8-dicyano-/2, 8-bis(benzo[d]thiazol-2-yl)-substituted derivatives
Irgashev, Roman A.,Kazin, Nikita A.,Rusinov, Gennady L.,Charushin, Valery N.
, p. 203 - 220 (2018/09/10)
A number of 5, 11-dialkyl-6, 12-di(hetero)aryl-5, 11-dyhydroindolo[3, 2-b]carbazoles has been synthesized by modified method based on HBr catalyzed condensation of (hetero)aromatic aldehydes with indole in MeCN solution affording 5, 6, 11, 12-tetrahydroindolo[3, 2-b]carbazoles, that have been aromatized with I2 in DMF solution for 1 h at reflux, followed by alkylation of 5, 11-dihydro compounds. New 2, 8-dicyano-(10 examples) as well as 2, 8-bis(benzo[d]thiazol-2-yl)-substituted (5 examples) derivatives of these 5, 11-dyhydroindolo[3, 2-b]carbazoles have been obtained through their initial C2, 8-formylation, followed by treatment of dialdehydes with excess of hydroxylamine and dehydration of the formed aldoximes with acetic anhydride or by interaction with excess of 2-aminothiophenol in DMSO solution, respectively.
Efficient and stable DSSC sensitizers based on substituted dihydroindolo[2,3-b]carbazole donors with high molar extinction coefficients
Cai, Shengyun,Tian, Guojian,Li, Xin,Su, Jianhua,Tian, He
, p. 11295 - 11305 (2013/09/23)
Four novel metal-free organic sensitizers based on 5,7-dihexyl-6,12- diphenyl-5,7-dihydroindolo[2,3-b]carbazole (DDC) donors have been synthesized. Their optical/electrochemical properties, dye-sensitized solar cell (DSSCs) performances and photo-stability upon successive irradiation for 30 min have been investigated. The optical data indicates that all these dyes showed a high molar extinction coefficient (5.6-6.3 × 104 M-1 cm-1). Under standard global AM 1.5 solar light condition, the DDC4 sensitized cell gave a short circuit photocurrent density (Jsc) of 14.81 mA cm-2, an open circuit voltage (Voc) of 0.688 V, and a fill factor (FF) of 0.69, corresponding to an overall efficiency (η) of 7.03%. The benzothiadiazole units and thieno[3,2-b]thiophene (TT) in the π spacer were found to increase the photo-stability of the corresponding dyes and these dyes based on this donor are promising candidates for the further application in DSSCs.
Synthesis of novel 2,8-disubstituted indolo[3,2-b]carbazoles
Van Snick, Sven,Dehaen, Wim
scheme or table, p. 79 - 82 (2012/01/06)
A new synthetic pathway towards 2,8-difunctionalised indolo[3,2-b] carbazoles was investigated. The presented method offers a short and high yielding route towards 2,8-dibromo-5,11-dihexyl-6,12-diphenyl-indolo[3,2-b] carbazole. It is demonstrated that the latter compound is a versatile building block, enabling the synthesis of a number of previously unreported 5,11-dialkyl-6,12-diphenyl-indolo[3,2-b]carbazoles in moderate to good yields, using Suzuki and Sonogashira cross-coupling reaction. Furthermore it is shown that 2,8-dibromo-5,11-dihexyl-6,12-diphenyl-indolo[3,2-b]carbazole can be easily formylated, giving rise to the 2,8-diformyl-5,11-dihexyl-6,12-diphenyl-indolo- [3,2-b]carbazole. The latter compound was successfully subjected to condensation reactions.
Novel synthesis of 6,12-dihydroindolo[3,2-b]carbazoles catalysed by p-toluenesulfonic acid
Jin, Can,Zhang, Bo,Yu, Chuanming,Su, Weike
scheme or table, p. 191 - 194 (2009/10/15)
An efficient and straightforward procedure for the synthesis of 6,12-dihydroindolo[3,2-b]carbazoles has been achieved through the one-pot reaction of indole with aromatic aldehydes in the presence of p-toluenesulfonic acid (pTSA) as the catalyst.
