296797-45-0

Upstream product

• 105-39-5 chloroacetic acid ethyl ester 
• 82127-15-9 4-(4-chlorophenyl)-6-(thien-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 79442-37-8 3-(4-chlorophenyl)-1-(thiophen-2-yl)prop-2-en-1-one 
• 300844-09-1 [4-(4-chloro-phenyl)-3-cyano-6-thiophen-2-yl-pyridin-2-ylsulfanyl]-acetic acid ethyl ester 

Downstream Products

• 299168-73-3 3-amino-4-(p-chlorophenyl)-6-(2'-thienyl)-thieno[2,3-b]pyridine-2-carboxamide 
• 847976-64-1 3-amino-4-(4-chloro-phenyl)-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carbonyl azide 

Relevant academic research and scientific papers

Synthesis and reactions of some pyridopyrimidine and thienopyridine derivatives for antiviral evaluation

COMPOUNDS 6-amino-4-(4-chlorophenyl)-2-thien-2-ylpyridine5-carbonitrile (2) and 4-(4-chlorophenyl)-6-thioxo-2-thien-2-yll,6-dihydropyridine-5-carbonitrile (9) were prepaied using 3-(4-chlorophenyl)-l-thien-2-ylpropenone (I) and malononitrile or cyanothioacetamide, respectively. Pyridine derivative 2 was in turn used as a precursor for preparation of some pyridopyrimidine and fused pyridopyrimidine derivatives 3-8. On the other hand, the pyridine derivative 9 was used in preparation of thienopyridine derivatives 10 and 11. Moreover, fusion of compound 11 with excess of benzoyl chloride ' afforded 4-(4-chlorophenyl)-2-phenyl-7-thien-2-yl-3H-pyrido [3′,2′:4,5] thieno[3,2-d] pyrimidin-4-one (12).

Synthesis and reactions of some new heterocyclic compounds containing the thienylthieno[2,3-b]pyridine moiety

(4-Aryl-3-cyano-6-(2-thienyl)pyridin-2-ylthio)acethydrazides (5a-c), 3-amino-4-aryl-6-(2-thienyl)thieno[2,3-b]pyridine-2-carbohydrazides (6a-c) and 3-amino-4-phenyl-6-(2-thienyl)thieno[2,3-b]pyridine-2-carboxylic acid (30) were prepared and employed as key intermediates in the synthesis of the title compounds.