299168-73-3

Basic information

• Product Name: Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-4-(4-chlorophenyl)-6-(2-thienyl)-
• CAS NO: 299168-73-3
• Molecular Formula: C18H12ClN3OS2
• Molecular Weight: 385.898
• Mol File: 299168-73-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-4-(4-chlorophenyl)-6-(2-thienyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-4-(4-chlorophenyl)-6-(2-thienyl)-(299168-73-3)
• EPA Substance Registry System: Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-4-(4-chlorophenyl)-6-(2-thienyl)-(299168-73-3)

Safety Data

• Hazardous Substances Data: 299168-73-3(Hazardous Substances Data)

Upstream product

• 296797-45-0 3-amino-4-(4-chlorophenyl)-6-thien-2-ylthieno[2,3-b]pyridine-2-carboxylic acid ethyl ester 
• 39145-33-0 2-cyano-3-(4-chlorophenyl)-prop-2-enethioamide 
• 88-15-3 2-Acetylthiophene 
• 326-91-0 1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione 
• 6028-96-2 (E)‐3‐(4‐chlorophenyl)‐1‐(thiophen‐2‐yl)prop‐2‐en‐1‐one 
• 296798-15-7 (4-(p-chlorophenyl)-3-cyano-6-(2'-thienyl)-2-pyridinylthio)acetamide 
• 82127-15-9 4-(4-chlorophenyl)-6-(thien-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 79-07-2 Chloroacetamide 
• 68029-53-8 (E)-3-(4-chlorophenyl)-2-cyanoprop-2-enethioamide 

Relevant articles and documents

Synthesis and reactions of some pyridopyrimidine and thienopyridine derivatives for antiviral evaluation

COMPOUNDS 6-amino-4-(4-chlorophenyl)-2-thien-2-ylpyridine5-carbonitrile (2) and 4-(4-chlorophenyl)-6-thioxo-2-thien-2-yll,6-dihydropyridine-5-carbonitrile (9) were prepaied using 3-(4-chlorophenyl)-l-thien-2-ylpropenone (I) and malononitrile or cyanothioacetamide, respectively. Pyridine derivative 2 was in turn used as a precursor for preparation of some pyridopyrimidine and fused pyridopyrimidine derivatives 3-8. On the other hand, the pyridine derivative 9 was used in preparation of thienopyridine derivatives 10 and 11. Moreover, fusion of compound 11 with excess of benzoyl chloride ' afforded 4-(4-chlorophenyl)-2-phenyl-7-thien-2-yl-3H-pyrido [3′,2′:4,5] thieno[3,2-d] pyrimidin-4-one (12).

Some reactions of 2-functionalized 3-amino-4-aryl-6-(2′-thienyl)-thieno[2,3-B]-pyridines: Synthesis of new pyridothienopyrimidines, pyridothienotriazines and related fused tetracyclic systems

4-Aryl-3-cyano-6-(2′-thienyl)-pyridine-2(1H)-thiones (2a-c) were prepared and reacted with chloroacetonitrile or chloroacetamide to furnish 3-amino-4-aryl-6-(2′-thienyl)-thieno[2,3-b]pyridine-2-carbonitriles (4a-c) and 2-carboxamide analogs 6a-c respectiv