29688-11-7

Upstream product

• 58755-70-7 1-iodo-4-methoxy-2-nitrobenzene 
• 959144-33-3 4-methoxy-2-nitro-1-[(trifluormethyl)thio]benzene 
• 959144-34-4 4-methoxy-2-nitrophenyl trifluoromethylsulfoxide 
• 22351-79-7 2,4-dinitrophenyl trifluoromethyl sulfone 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 

Downstream Products

• 959144-35-5 2-fluoro-4-methoxyphenyl trifluoromethylsulfone 
• 959144-36-6 2-fluoro-4-hydroxyphenyl trifluoromethylsulfone 

Relevant academic research and scientific papers

NOVEL INHIBITORS OF BETA-LACTAMASE

This invention provides novel β-lactamase inhibitors of the aryl- and heteroarylsulfonamidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammonium groups. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazidime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases. Formula (I) or pharmaceutically acceptable salt thereof.

NOVEL SULFONAMIDOMETHYLPHOSPHONATE INHIBITORS OF BETA-LACTAMASE

This invention provides novel β-lactamase inhibitors of the aryl-and heteroaryl-sulfonamidomethylphosphonate monoester class. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazimdime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases. Formula (I) or a pro-drug or pharmaceutically acceptable salt thereof, wherein: W represents: Formula (II).