297137-20-3Relevant academic research and scientific papers
Synthesis and antitumor activity of duocarmycin derivatives: A-ring pyrrole compounds bearing β-(5',6',7'-trimethoxy-2'-indolyl)acryloyl group
Amishiro, Nobuyoshi,Nagamura, Satoru,Kobayashi, Eiji,Okamoto, Akihiko,Gomi, Katsushige,Okabe, Masami,Saito, Hiromitsu
, p. 1637 - 1643 (2000)
A series of A-ring pyrrole derivatives of duocarmycin bearing β-(5',6',7'-trimethoxy-2'-indolyl)acryloyl group were synthesized, and evaluated for in vitro anticellular activity against HeLa S3 cells and in vivo antitumor activity against murine sarcoma 180 in mice. New Seg-B analogues bearing β-(5',6',7'-trimethoxy-2'-indolyl)acryloyl group containing double bond as spacer had lower peripheral blood toxicity than the derivatives bearing 5',6',7'-trimethoxyindole-2'-carboxyl group in Seg-B of the natural type. Moreover, most of them exhibited potent antitumor activity against in vivo murine tumor models. Copyright (C) 2000 Elsevier Science Ltd.
