2972-79-4

Usage

Uses

Used in Law Enforcement and Military Applications:
2,6-DICHLOROBENZALMALONONITRILE is used as a riot control agent for its ability to disperse and control crowds during civil unrest or demonstrations. Its application is primarily due to the temporary incapacitation and discomfort it causes when inhaled or when it comes into contact with the skin, which helps in maintaining public order and safety.
Used in Crowd Dispersal:
2,6-DICHLOROBENZALMALONONITRILE is used as a crowd dispersal tool for its effectiveness in causing intense irritation to the eyes, skin, and respiratory system. This leads to individuals in the affected area seeking to move away from the source of the gas, thereby achieving the goal of crowd dispersion.
Used in Non-Lethal Force:
2,6-DICHLOROBENZALMALONONITRILE is used as a non-lethal force agent in situations where law enforcement or military personnel need to control a crowd without resorting to lethal methods. Its temporary incapacitating effects make it a preferred choice for minimizing harm to both the public and the authorities involved in crowd management.

InChI:InChI=1/C10H4Cl2N2/c11-9-2-1-3-10(12)8(9)4-7(5-13)6-14/h1-4H

Upstream product

• 83-38-5 2,6-dichlorobenzaldehyde 
• 109-77-3 malononitrile 

Downstream Products

• 28989-26-6 3-chloro-5-(2,6-dichlorophenyl)-4-isothiazolecarbonitrile 
• 121361-35-1 2,7-diamino-5-(2,6-dichlorophenyl)-4,5-dihydro-pyrazolo<1,5-a>pyrimidine-3,6-dicarbonitrile 
• 133839-36-8 (2R,3R,8aS)-1,1,6-Tricyano-2-(2,6-dichloro-phenyl)-1,2,3,8a-tetrahydro-indolizine-3-carboxylic acid amide 
• 121361-37-3 7-amino-5-(2,6-dichlorophenyl)-2(4-morpholinyl)-4,5-dihydro-pyrazolo<1,5-a>pyrimidine-3,6-dicarbonitrile 
• 475197-85-4 2-(2,6-dichlorobenzyl)malononitrile 
• 1285689-63-5 4-(2,6-dichlorobenzyl)-1H-pyrazole-3,5-diamine 
• 346436-66-6 2-amino-4-(2,6-dichlorophenyl)-4H-benzo[h]chromene-3-carbonitrile 
• 299202-11-2 6-amino-3-methyl-4-(2,6-dichlorophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 
• 332052-24-1 ethyl 6-amino-5-cyano-4-(2,6-dichlorophenyl)-2-phenyl-4H-pyran-3-carboxylate 

Relevant academic research and scientific papers

The Knoevenagel reaction: Analysis and recycling of the ionic liquid medium

A study involving the scope of substrate in the Knoevenagel reaction in an IL medium has been conducted. Reactivity trends favor formation of the condensation product using electron deficient aryl aldehydes. Use of electron rich aldehydes and ketones lead

Design, synthesis and biological evaluation of new series of hexahydroquinoline and fused quinoline derivatives as potent inhibitors of wild-type EGFR and mutant EGFR (L858R and T790M)

New series of hexahydroquinoline and fused quinoline derivatives were designed and synthesized. The thirty seven new compounds were screened for in vitro antitumor activity against HepG2, HCT-116 and MCF-7 cancer cells. Results indicated that compounds 2e

A Simplistic Approach for Preparation of Alkylidenemalononitrile Derivatives: Characterization, In silico Studies, Quantum Chemical Evaluation, Molecular Docking, and In vitro Biological Activity Evaluation

A new and efficient green grinding-based catalyst free Knoevenagel condensation of aldehydes/ketones and malononitrile for the rapid preparation of twelve malononitrile derivatives (C1-C12) is proposed. Characterization of the derivatives was done by sup

Highly active zinc oxide-supported lithium oxide catalyst for solvent-free Knoevenagel condensation

Li2O/ZnO catalyst was prepared by wet impregnation method and characterized by XRD, SEM, EDX, FTIR, BET surface area and UV-Vis diffuse reflectance spectroscopy. This study revealed a decrease in average particle size and change in the shape of

Enzymes inhibition profiles and antibacterial activities of benzylidenemalononitrile derivatives

The activities of enzymes can be targeted in the treatment of some diseases. Recently, this strategy has been used frequently in the development of new drugs. Carbonic anhydrase isozymes (CA-I and CA-II) and acetylcholine esterase (AChE) are some of these

1,4,5,6,7,8-Hexahydroquinolines and 5,6,7,8-tetrahydronaphthalenes: A new class of antitumor agents targeting the colchicine binding site of tubulin

New series of 2-amino-1,4,5,6,7,8-hexahydroquinoline-3-carbonitriles 3a,b and 2-amino-5,6,7,8-tetrahydronaphthalene-1,3-dicarbonitriles 4a-h were synthesized and evaluated for their antitumor activity. In vitro antitumor screening of the new members again

Synthesis of multifunctional polymer containing Ni-Pd NPs via thiol-ene reaction for one-pot cascade reactions

Recently, acid–base bifunctional catalysts have been considered due to their abilities, such as the simultaneous activation of electrophilic and nucleophilic species and their high importance in organic syntheses. However, the synthesis of acid–base catalysts is problematic due to the neutralization of acidic and basic groups. This work reports a facial approach to solve this problem via the synthesis of a novel bifunctional polymer using inexpensive materials and easy methods. In this way, at the first step, heterogeneous poly (styrene sulfonic acid-n-vinylimidazole) containing pentaerythritol tetra-(3-mercaptopropionate) (PETMP) and trimethylolpropane trimethacrylate (TMPTMA) cross-linkers were synthesized in the pores of a mesoporous silica structure using click reaction as a novel bifunctional acid–base catalyst. After that, Ni-Pd nanoparticles supported on poly (styrenesulfonic acid-n-vinylimidazole)/KIT-6 as a novel trifunctional heterogeneous acid–base-metal catalyst was prepared. The prepared catalysts were characterized by various techniques like FT-IR, TGA, ICP-AES, DRS-UV, TEM, FE-SEM, EDS-Mapping, and XRD. The synthesized catalysts were efficiently used as bifunctional/trifunctional catalysts for one-pot, deacetalization-Knoevenagel condensation and one-pot, three-step and a sequential reaction containing deacetalization-Knoevenagel condensation-reduction reaction. It is important to note that the synthesized catalyst showing high chemo-selectivity for the reduction of nitro group, alkenyl double bond and ester group in the presence of nitrile. Moreover, it was found that the different nanoparticles including Ni, Pd, and alloyed Ni-Pd showing different chemo-selectivity and catalytic activity in the reaction.

Dihydro-2: H -thiopyran-3(4 H)-one-1,1-dioxide-a versatile building block for the synthesis of new thiopyran-based heterocyclic systems

Three series of new cyclic sulfones have been prepared by a one-pot multi-component reaction (MCR) starting from the readily available dihydro-2H-thiopyran-3(4H)-one-1,1-dioxide. The in silico screening of the synthesized compounds revealed their high anti-inflammatory, antiarthritic, antiasthmatic and antiallergic potential coupled with the strong probability levels of cystinyl aminopeptidase inhibition. The key structures were confirmed by 2D NMR techniques.

Effective and Green One-Pot Multicomponent Synthesis of Novel Derivatives of 4H-Pyrans in the Presence of Hexamethylenetetramine as Catalyst in Water Medium

Hexamethylenetetramine catalyzes synthesis of new polyfunctionalized 4H-pyrans by the reaction of aromatic aldehyde, malononitrile, and β-keto esters via one-pot three-component procedure in water medium. Addition of reactants was performed by two methods

RETRACTED ARTICLE: Effective and Green One-Pot Multicomponent Synthesis of Novel Derivatives of 4H-Pyrans in the Presence of Hexamethylenetetramine as Catalyst in Water Medium

Hexamethylenetetramine (HMTA) catalyzes synthesis of new polyfunctionalized 4H-pyrans by reaction of aromatic aldehyde, malononitrile, and β-keto esters via one-pot three-component procedure in water medium. Addition of reactants was performed by two meth