299202-11-2

Upstream product

• 83-38-5 2,6-dichlorobenzaldehyde 
• 108-26-9 3-methyl-2-pyrazoline-5-one 
• 109-77-3 malononitrile 
• 2972-79-4 2-(2,6-dichlorobenzylidene)malononitrile 
• 132712-71-1 5-hydroxy-3-methylpyrazole 
• 141-97-9 ethyl acetoacetate 

Relevant academic research and scientific papers

Fast synthesis of pyrano[2,3-c]pyrazoles: Strong effect of Br?nsted and Lewis acidic ionic liquids

Abstract In a unique approach, four-component synthesis of some pyrano[2,3-c]pyrazoles by [ChCl][ZnCl2]2 and [H-NMP]HSO4 as inexpensive and recyclable acidic ionic liquids were investigated. Excellent yields of products we

Design and development of a new functionalized cellulose-based magnetic nanocomposite: preparation, characterization, and catalytic application in the synthesis of diverse pyrano[2,3-c]pyrazole derivatives

In this work, a facile protocol for the preparation of a new cellulose-based functionalized magnetic nanocomposite catalyst is described. The structure and morphology of the prepared nanomaterial was characterized by scanning electron microscopy, energy-d

Dihydropyrano [2,3-c] pyrazole: Novel in vitro inhibitors of yeast α-glucosidase

Inhibition of α-glucosidase enzyme activity is a reliable approach towards controlling post-prandial hyperglycemia associated risk factors. During the current study, a series of dihydropyrano[2,3-C] pyrazoles (1-35) were synthesized and evaluated for thei

One-pot synthesis of pyrano[2,3-c]pyrazoles using SBA-15-PR-NH2 and their antimicrobial activities

A simple, green, convenient and efficient method for the synthesis of 6-amino-5-cyanodihydropyrano[2,3-c]pyrazoles 4 is developed through one-pot, three component condensation of 3-methyl-1Hpyrazole-5(4H)-one 1, malononitrile 2, and aromatic aldehydes 3 under mild reaction condition using propylamine functionalized nanoporous silica (SBA-Pr-NH2) as a heterogeneous solid base catalyst. Antimicrobial activity of some synthesized pyrano[2,3-c]pyrazoles against Bacillus subtilis, Staphylococcus aureus and Escherichia coli were measured using disc diffusion method.

Rapid one-pot, four component synthesis of pyranopyrazoles using heteropolyacid under solvent-free condition

A series of pyranopyrazoles, was efficiently synthesized via one-pot, four component reaction of ethyl acetoacetate, hydrazine hydrate, aldehydes and malononitrile in the presence of catalytic amount silicotungstic acid under solvent free condition. NOE e

Synthesis of substituted pyranopyrazoles under neat conditions via a multicomponent reaction

A simple and efficient synthesis of pyranopyrazoles in good yields via a four-component reaction between an aromatic aldehyde, hydrazine hydrate, ethyl acetoacetate and malononitrile under neat conditions is described. Georg Thieme Verlag Stuttgart.

A new convenient four-component synthesis of 6-amino-2H,4H-pyrano[2,3-c] pyrazole-5-carbonitriles and one-pot synthesis of 6′-amino-5′-cyano- 1,2-dihydrospiro- [(3H)-indole-3,4′-(4′H)-pyrano[2,3-c]pyrazol]-2- ones

A new convenient method for the synthesis of 6-amino-2H,4H-pyrano[2,3-c] pyrazole-5-carbonitriles, namely, four-component condensation of carbonyl compounds (aromatic aldehydes, heterocyclic ketones), malononitrile, ss-keto esters, and hydrazine hydrate in ethanol in the presence of triethylamine as a catalyst, which occurs selectively, is developed. One-pot two-step modification of this method is proposed for the synthesis of spiro[(3H)-indole-3,4′-(4′H)-pyrano[2,3-c]pyrazol]-2-ones.