2973-26-4

Upstream product

• 612-96-4 2-Phenylquinoline 
• 506-68-3 bromocyane 
• 74-90-8 hydrogen cyanide 
• 71-43-2 benzene 
• 5807-02-3 4-morpholinoacetonitrile 
• 21236-85-1 quinoline-4-carbonitrile 1-oxide 
• 98-80-6 phenylboronic acid 
• 132-60-5 cinchophen 
• 107-13-1 acrylonitrile 
• 1750-36-3 (E)-N-benzylidenebenzenamine 
• 29197-45-3 2-phenyl quinoline-4-carboxamide 

Downstream Products

• 29312-45-6 1-oxy-2-phenyl-quinoline-4-carbonitrile 
• 74831-35-9 C₂₂H₁₅N₂O 
• 74831-37-1 1-Hydroxy-2,2-diphenyl-1,2-dihydro-quinoline-4-carbonitrile 
• 25888-54-4 2-phenyl-quinoline-4-carbothioic acid amide 
• 114493-14-0 2-phenyl-quinoline-4-carbonimidic acid-(N-methyl-anilide) 
• 114509-69-2 2-phenyl-quinoline-4-carbonimidic acid-[2]naphthylamide 
• 110195-24-9 2-phenyl-quinoline-4-carbonimidic acid anilide 
• 110330-72-8 2-phenyl-quinoline-4-carbonimidic acid diethylamide 
• 114493-15-1 2-phenyl-quinoline-4-carbonimidic acid p-toluidide 
• 106883-96-9 2-phenyl-quinoline-4-carbonimidic acid amide 
• 7505-73-9 1-(2-phenylquinolin-4-yl)ethan-1-one 
• 78812-01-8 4-Guanidinomethyl-2-phenylquinoline hydrochloride 

Relevant academic research and scientific papers

Direct arylation for the synthesis of 2-arylquinolines from N-methoxyquinoline-1-ium tetrafluoroborate salts and arylboronic acids

A rapid and direct arylation reaction of N-methoxyquinoline-1-ium tetrafluoroborate derivatives and arylboronic acids with high regioselectivety at room temperature was discovered. The reaction shows exceptional functional group tolerance and broad substrate scope regarding both the quinoline derivatives and the arylboronic acids.

Decarbonylative Synthesis of Aryl Nitriles from Aromatic Esters and Organocyanides by a Nickel Catalyst

A decarbonylative cyanation of aromatic esters with aminoacetonitriles in the presence of a nickel catalyst was developed. The key to this reaction was the use of a thiophene-based diphosphine ligand, dcypt, permitting the synthesis of aryl nitrile without the generation of stoichiometric metal- or halogen-containing chemical wastes. A wide range of aromatic esters, including hetarenes and pharmaceutical molecules, can be converted into aryl nitriles.

QUINOLINES DERIVATIVES AS NOVEL ANTICANCER AGENTS

The invention provides quinoline derivatives, their manufacture, pharmaceutical compositions containing them, and their use as medicaments. The active compounds of the present invention are useful for the treatment of proliferative neoplastic and nonneoplastic diseases.

THE REACTION OF IMIDOYL RADICALS WITH MULTIPLE CARBON-CARBON BONDS

A general view on the reaction between imidoyl radicals and carbon-carbon double or triple bonds is given; the synthesis of substituted quinolines starting from imines and alkenes is described, pointing out the differences with respect to the analogous reaction performed with alkynes.

Quinoline Nitroxide Radicals. Ipso-Attack in the Reaction between 2-Methoxy and 2-Cyanoquinoline N-oxide, and Phenylmagnesium Bromide

2-Methoxy and 2-cyanoquinoline N-oxide, when treated with phenylmagnesium bromide, undergo a nucleophilic ipso-attack at C-2, yielding, by elimination of methoxymagnesium bromide or cyanomagnesium bromide, the corresponding 2-phenylquinoline N-oxides, which react with the excess of Grignard reagents forming 2,2-diphenylquinoline 1-oxyls.Even when the methoxy and cyano groups are in position 4, the attack by the Grignard reagent takes place at C-2 giving 2-phenylquinolines and 2-phenylquinoline N-oxides by elimination by hydroxymagnesium bromide and bromomagnesium hydride, respectively; the formation of 2,2-diphenylquinoline 1-oxyls in these reactions is discussed.