2976-66-1Relevant articles and documents
Negishi coupling of secondary alkylzinc halides with aryl bromides and chlorides
Han, Chong,Buchwald, Stephen L.
supporting information; experimental part, p. 7532 - 7533 (2009/10/16)
(Chemical Equation Presented) An efficient palladium-catalyzed process has been developed for Negishi coupling of secondary alkylzinc halides with a wide range of aryl bromides and activated aryl chlorides. A palladium catalyst composed of a new biaryldialkylphosphine ligand, CPhos, effectively promotes the rate of the reductive elimination step relative to the rate of the undesired β-hydride elimination. The broad substrate scope and excellent ratio of the desired secondary to the undesired primary coupling product make this method a powerful and reliable tool forC(sp3)-C(sp2) bond formation.
