77047-87-1

Basic information

• Product Name: 2-PROPYLZINC BROMIDE SOLUTION 0.5M IN T&
• Synonyms: 2-PROPYLZINC BROMIDE SOLUTION 0.5M IN T&;2-propylzinc bromide solution;isopropylzinc bromide;2-Propylzinc bromide solution 0.5 in THF;Isopropylzinc broMide, 0.5M in THF, packaged under Argon in resealable CheMSeal^t bottles;2-Propylzinc broMide solution 0.5 M in THF;2-Propylzinc broMide, 0.5 M solution in THF, SpcSeal;Zinc,bromo(1-methylethyl)- (9CI)
• CAS NO: 77047-87-1
• Molecular Formula: C₃H₇BrZn
• Molecular Weight: 188.38168
• Mol File: 77047-87-1.mol
• Article Data: 6

Chemical Properties

• Flash Point: -20 °C
• Appearance: /
• Density: 0.963 g/mL at 25 °C
• Storage Temp.: 2-8°C
• Water Solubility: Reacts with water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-PROPYLZINC BROMIDE SOLUTION 0.5M IN T&(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PROPYLZINC BROMIDE SOLUTION 0.5M IN T&(77047-87-1)
• EPA Substance Registry System: 2-PROPYLZINC BROMIDE SOLUTION 0.5M IN T&(77047-87-1)

Safety Data

• Hazard Codes: F+,Xi,Xn,F
• Statements: 11-19-36/37/38-40-14/15
• Safety Statements: 7-26-43-36/37-16
• RIDADR: UN 3399 4.3/PG 2
• WGK Germany: 3
• HazardClass: 4.3
• Hazardous Substances Data: 77047-87-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 77047-87-1 differently. You can refer to the following data:
1. Isopropylzinc bromide is employed in croos-coupling reactions.
2. 2-Propylzinc bromide solution (0.5 M in THF) has been used as a reagent in a protocol for the nickel-catalyzed dehalogenation of organic halides.

InChI:InChI=1/C3H7.BrH.Zn/c1-3-2;;/h3H,1-2H3;1H;/q;;+1/p-1/rC3H7BrZn/c1-3(2)5-4/h3H,1-2H3

Upstream product

• 75-26-3 isopropyl bromide 
• 7440-66-6 zinc 

Downstream Products

• 65860-53-9 2-isopropyl-3-butenoic acid 
• 1606-47-9 isopropyl vinyl ketone 
• 13816-33-6 p-Cyanocumen 
• 97820-51-4 5-(isopropyl)-1H-indole 
• 4132-48-3 1-methoxy-4-(1-methylethyl)benzene 
• 40751-52-8 2-Isopropyl-1-benzonitrile 
• 2944-47-0 o-isopropylanisole 
• 6623-98-9 2-Isopropylbenzoesaeuremethylester 
• 7116-95-2 4-isopropylbiphenyl 
• 20185-55-1 p-isopropylbenzoic acid methyl ester 
• 2976-66-1 1-isopropyl-2-methylsulfanyl-benzene 
• 122-03-2 (4-isopropylbenzaldehyde) 
• 1817-47-6 4-nitrocumene 
• 38071-66-8 methyl 5-isopropylfuran-2-carboxylate 

Relevant articles and documents

Efficient analoging around ethionamide to explore thioamides bioactivation pathways triggered by boosters in Mycobacterium tuberculosis

Ethionamide is a key antibiotic prodrug of the second-line chemotherapy regimen to treat tuberculosis. It targets the biosynthesis of mycolic acids thanks to a mycobacterial bioactivation carried out by the Baeyer-Villiger monooxygenase EthA, under the control of a transcriptional repressor called EthR. Recently, the drug-like molecule SMARt-420, which triggers a new transcriptional regulator called EthR2, allowed the derepression a cryptic alternative bioactivation pathway of ethionamide. In order to study the bioactivation of a collection of thioisonicotinamides through the two bioactivation pathways, we developed a new two-step chemical pathway that led to the efficient synthesis of eighteen ethionamide analogues. Measurements of the antimycobacterial activity of these derivatives, used alone and in combination with boosters BDM41906 or SMARt-420, suggest that the two different bioactivation pathways proceed via the same mechanism, which implies the formation of similar metabolites. In addition, an electrochemical study of the aliphatic thioisonicotinamide analogues was undertaken to see whether their oxidation potential correlates with their antitubercular activity measured in the presence or in the absence of the two boosters.

Highly regioselective three-component domino heck-negishi coupling reaction for the functionalization of purines at C6

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