29768-17-0Relevant articles and documents
Zwitterion-Catalyzed Deacylative Dihalogenation of β-Oxo Amides
Chan, Kin-San,Ke, Zhihai,Lam, Ying-Pong,Yeung, Ying-Yeung
supporting information, p. 7353 - 7357 (2020/10/02)
α,α-Dihalo-N-arylacetamides are commonly used as intermediates in various organic reactions. In the study described here, a catalytic synthesis of α,α-dihalo-N-arylacetamides from β-oxo amides was developed using zwitterionic catalysts and N-halosuccinimi
Divergent synthesis of α,α-dihaloamides through α,α-dihalogenation of β-oxo amides by using N-halosuccinimides
Wang, Jia,Li, Hongtao,Zhang, Dingyuan,Huang, Peng,Wang, Zikun,Zhang, Rui,Liang, Yongjiu,Dong, Dewen
, p. 5376 - 5380 (2013/09/02)
An efficient and divergent one-pot synthesis of α,α- dihaloamides from readily available β-oxo amides based on the selection of reaction conditions is reported. α,α-Dihalo-β-oxo amides were produced by treating β-oxo amides with N-chlorosuccinimide (NCS) or N-bromosuccinimide (NBS) in water at room temperature, whereas α,α-dihaloacetamides were synthesized by subjecting β-oxo amides to NCS or NBS in ethanol under reflux. A divergent synthesis of α,α-dihalo-β-oxo amides and α,α-dihaloacetamides has been developed from readily available β-oxo amides. Upon treatment with N-halosuccinimides in water at room temperature, α,α-dihalo-β- oxo amides were produced, whereas dihaloacetamides were synthesized by treatment of β-oxo amides with N-halosuccinimides in ethanol under reflux. Copyright
