2977-51-7

Basic information

• Product Name: Acetic acid, [2,3-dichloro-4-(1-oxobutyl)phenoxy]-, ethyl ester
• Synonyms: Acetic acid, [2,3-dichloro-4-(1-oxobutyl)phenoxy]-, ethyl ester
• CAS NO: 2977-51-7
• Molecular Formula: C₁₄H₁₆Cl₂O₄
• Molecular Weight: 319.18044
• Mol File: 2977-51-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Acetic acid, [2,3-dichloro-4-(1-oxobutyl)phenoxy]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, [2,3-dichloro-4-(1-oxobutyl)phenoxy]-, ethyl ester(2977-51-7)
• EPA Substance Registry System: Acetic acid, [2,3-dichloro-4-(1-oxobutyl)phenoxy]-, ethyl ester(2977-51-7)

Safety Data

• Hazardous Substances Data: 2977-51-7(Hazardous Substances Data)

Upstream product

• 2350-46-1 2',3'-dichloro-4'-hydroxybutyrophenone 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 58-54-8 ethacrynic acid 

Relevant articles and documents

Ethacrynic acid as a lead structure for the development of potent urease inhibitors

Ethacrynic acid and a series of its analogues were synthesized and subsequently evaluated for their inhibitory effect on jack bean urease. Ethacrynic acid showed, even at low concentrations, very potent inhibitory activity against the enzyme. For ethacrynic acid, the inhibition potential increased with increasing preincubation time of ethacrynic acid and enzyme, whereas for some other compounds a higher preincubation time lead to a significant reduction of their activity. We could demonstrate that the α,β-unsaturated carbonyl unit of our compounds is mandatory to inhibit the enzyme, possibly due to its ability to bind to cysteine residues in the active site of the jack bean urease.