298208-82-9

Upstream product

• 114371-50-5 1,1-dimethylethyl -<1-(cyclohexylmethyl)-4-hydroxy-2-butenyl>carbamate 
• 103322-56-1 tert-butyl [(1S)-2-cyclohexyl-1-(hydroxymethyl)ethyl]carbamate 
• 114371-49-2 ethyl -5-cyclohexyl-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-pentenoate 
• 98105-42-1 (S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal 

Downstream Products

• 257296-67-6 (4S-trans)-4,5-dihydro-4-cyclohexylmethyl-2-phenyl-5-vinyloxazoline 
• 257296-61-0 (-)-N-((2S,3S)-3-hydroxy-1-cyclohexyl-4-pentenyl)benzamide 
• 257296-73-4 (4S-trans)-4,5-dihydro-4-cyclohexylmethyl-5-(2-hydroxyethyl)-2-phenyloxazoline 
• 298208-78-3 (4S-trans)-4,5-dihydro-4-cyclohexylmethyl-2-phenyloxazoline-5-acetic acid 
• 257296-55-2 N-((2S)-5-acetoxy-1-cyclohexyl-3-butenyl)benzamide 

Relevant academic research and scientific papers

Stereoselective intramolecular cyclization of allyl and homoallyl benzamide via π-allylpalladium complex catalyzed by Pd(0)

The transformation of acyclic allylic benzamides 4 and homoallylic benzamides 12 to vinyl oxazolines 3 is achieved in the presence of base by the catalysis and Pd(0) in high yield and with high diastereoselectivity. Especially, in the case of homoallylic benzamides 12, trans-oxazolines 3 are formed exclusively or predominantly over cis-oxazolines 8, irrespective of the composition of their stereoisomers. The reaction is believed to proceed via the same π-allylpalladium complex that arises from either primary or secondary allylic acetates. We applied this method to the syntheses of β- amino-α-hydroxy acids 1 and γ-amino-β-hydroxy acids 2, conveniently protected as oxazoline.