298690-84-3

Basic information

• Product Name: 2-(4-Trifluoromethylphenyl)pyrrolidine
• Synonyms: 2-(4-TRIFLUOROMETHYL-PHENYL)-PYRROLIDINE;(2R)-2-[4-(TRIFLUOROMETHYL)PHENYL]PYRROLIDINE-HCL
• CAS NO: 298690-84-3
• Molecular Formula: C11H12F3N
• Molecular Weight: 215.21
• Product Categories: Benzenes
• Mol File: 298690-84-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 254.086 °C at 760 mmHg
• Flash Point: 107.468 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 0.0176mmHg at 25°C
• Refractive Index: 1.473
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-(4-Trifluoromethylphenyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Trifluoromethylphenyl)pyrrolidine(298690-84-3)
• EPA Substance Registry System: 2-(4-Trifluoromethylphenyl)pyrrolidine(298690-84-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 298690-84-3(Hazardous Substances Data)

Usage

General Description

2-(4-Trifluoromethylphenyl)pyrrolidine is a chemical compound with the molecular formula C11H13F3N. It is a pyrrolidine derivative, which is a class of organic compounds with a five-membered ring structure containing three carbon atoms and one nitrogen atom. This specific compound contains a pyrrolidine ring with a trifluoromethylphenyl group attached to it. It is used in the pharmaceutical industry as a building block in the synthesis of various drugs and has potential applications in medicinal chemistry and drug discovery. It is also used in research settings as a reference standard for analytical and spectroscopic purposes. The compound's properties and potential uses make it a valuable tool in drug development and chemical research.

InChI:InChI=1/C11H12F3N/c12-11(13,14)9-5-3-8(4-6-9)10-2-1-7-15-10/h3-6,10,15H,1-2,7H2

Upstream product

• 123-75-1 pyrrolidine 
• 2786-01-8 (4-trifluoromethylphenyl)lithium 
• 72216-08-1 2-(4-(trifluoromethyl)phenyl)-1-pyrroline 

Relevant articles and documents

Enantioselective Synthesis of 2-Substituted Pyrrolidines via Intramolecular Reductive Amination

Catalyzed by the complex generated in situ from iridium and the chiral ferrocene ligand, tert -butyl (4-oxo-4-arylbutyl)carbamate substrates were deprotected and then reductively cyclised to form 2-substituted arylpyrrolidines in a one-pot manner, in which the intramolecular reductive amination was the key step. A range of chiral 2-substituted arylpyrrolidines were synthesised in up to 98percent yield and 92percent ee.

Hammett correlation of nornicotine analogues in the aqueous aldol reaction: Implications for green organocatalysis

(Chemical Equation Presented) A series of meta- and para-substituted 2-arylpyrrolidines were synthesized and examined for their ability to catalyze an aqueous aldol reaction under buffered conditions. Kinetic analysis of arylpyrrolidine-catalyzed reactions displayed a linear Hammett correlation with ρ = 1.14 (R2 = 0.996), indicating that the reaction is accelerated by electron-withdrawing aryl rings. These results show promise for the development of a synthetically viable aqueous organocatalyst.