29880-63-5

Basic information

• Product Name: 1-(5-tert-butylthiophen-2-yl)ethanone
• CAS NO: 29880-63-5
• Molecular Formula: C₁₀H₁₄OS
• Molecular Weight: 182.2826
• Mol File: 29880-63-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 249.5°C at 760 mmHg
• Flash Point: 104.7°C
• Density: 1.029g/cm³
• Vapor Pressure: 0.0228mmHg at 25°C
• Refractive Index: 1.51
• CAS DataBase Reference: 1-(5-tert-butylthiophen-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-tert-butylthiophen-2-yl)ethanone(29880-63-5)
• EPA Substance Registry System: 1-(5-tert-butylthiophen-2-yl)ethanone(29880-63-5)

Safety Data

• Hazardous Substances Data: 29880-63-5(Hazardous Substances Data)

Usage

General Description

1-(5-tert-butylthiophen-2-yl)ethanone is a chemical compound with a molecular formula C12H16OS. It is a pale yellow liquid with a strong odor, and is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. The structure of this chemical features a thiophene ring substituted with a tert-butyl group and an ethanone group, which gives it its unique properties. It is important to handle this compound with caution, as it may cause irritation to the skin, eyes, and respiratory system, and should be stored and used in a well-ventilated area.

Upstream product

• 1689-78-7 2-tert-butylthiophene 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 88-15-3 2-Acetylthiophene 
• 38442-51-2 tert-butylmercury chloride 
• 5370-25-2 2-Acetyl-5-bromothiophene 

Downstream Products

• 29212-25-7 5-(tert-butyl)thiophene-2-carboxylic acid 
• 102600-80-6 (+/-)-1-(5-tert-butyl-[2]thienyl)-3ξ-(2,6,6-trimethyl-cyclohex-2-enyl)-propenone 
• 15898-92-7 6,6-Dimethyloenanthsaeure 
• 685120-65-4 5-tert-butyl-thiophene-2-carboxylic acid amide 
• 832113-93-6 5-tert-butyl-2-thiophenecarboxylic acid chloride 

Relevant articles and documents

Acid- or base-promoted photostimulated homolytic tert-butylation of pyridines and thiophenes

Regioselective photostimulated homolytic tert-butylations for heteroaromatics such as pyridines or thiophenes are investigated with tert-butylmercury(II) chloride in the presence of toluene-p-sulfonic acid (PTSA) or 1,4-diaza-bicyclo[2.2.2]octane (DABCO)

SYNTHESIS AND ELECTROPHILIC TRICHLOROMETHYLATION OF 2,4-DIALKYLTHIOPHENES. SOME TRANSFORMATIONS OF 2,4-DI-tert-BUTYL-5-(TRICHLOROMETHYL)THIOPHENE

The disproportionation products of the C-protonation of 5-tert-butyl-2-methyl- and 2-ethylthiophene first give 4-tert-butyl-2-methyl- and 2-ethylthiophene. We studied the electrophilic trichloromethylation of a series of 2,4-dialkyl thiophenes and showed that the reaction goes smoothly only for the most sterically hindered 2,4-di-tert-butyl-thiophene. We studied the reaction of 2,4-di-tert-butyl-5-(trichloromethyl)thiophene with some O- and N-nucleophiles.