29880-63-5

Usage

Physical state

Pale yellow liquid

Odor

Strong

Usage

Intermediate in the synthesis of pharmaceuticals and other organic compounds

Chemical structure

Thiophene ring substituted with a tert-butyl group and an ethanone group

Safety precautions

Handle with caution, may cause irritation to skin, eyes, and respiratory system

Storage and usage

Store and use in a well-ventilated area

Upstream product

• 5370-25-2 2-Acetyl-5-bromothiophene 
• 88-15-3 2-Acetylthiophene 
• 38442-51-2 tert-butylmercury chloride 
• 1689-78-7 2-tert-butylthiophene 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 102600-80-6 (+/-)-1-(5-tert-butyl-[2]thienyl)-3ξ-(2,6,6-trimethyl-cyclohex-2-enyl)-propenone 
• 15898-92-7 6,6-Dimethyloenanthsaeure 
• 685120-65-4 5-tert-butyl-thiophene-2-carboxylic acid amide 
• 832113-93-6 5-tert-butyl-2-thiophenecarboxylic acid chloride 
• 29212-25-7 5-(tert-butyl)thiophene-2-carboxylic acid 

Relevant academic research and scientific papers

Acid- or base-promoted photostimulated homolytic tert-butylation of pyridines and thiophenes

Regioselective photostimulated homolytic tert-butylations for heteroaromatics such as pyridines or thiophenes are investigated with tert-butylmercury(II) chloride in the presence of toluene-p-sulfonic acid (PTSA) or 1,4-diaza-bicyclo[2.2.2]octane (DABCO)

Enabling the Cross-Coupling of Tertiary Organoboron Nucleophiles through Radical-Mediated Alkyl Transfer

The construction of quaternary centers is a common challenge in the synthesis of complex materials and natural products. Current cross-coupling strategies that can be generalized for setting these centers are sparse and, when known, are typically predicated on the use of reactive organometallic reagents. To address this shortcoming a new, photoredox-Ni dual catalytic strategy for the cross-coupling of tertiary organoboron reagents with aryl halides is reported. In addition to details on the cross-coupling scope and limitations, full screening efforts and mechanistic experiments are communicated.

SYNTHESIS AND ELECTROPHILIC TRICHLOROMETHYLATION OF 2,4-DIALKYLTHIOPHENES. SOME TRANSFORMATIONS OF 2,4-DI-tert-BUTYL-5-(TRICHLOROMETHYL)THIOPHENE

The disproportionation products of the C-protonation of 5-tert-butyl-2-methyl- and 2-ethylthiophene first give 4-tert-butyl-2-methyl- and 2-ethylthiophene. We studied the electrophilic trichloromethylation of a series of 2,4-dialkyl thiophenes and showed that the reaction goes smoothly only for the most sterically hindered 2,4-di-tert-butyl-thiophene. We studied the reaction of 2,4-di-tert-butyl-5-(trichloromethyl)thiophene with some O- and N-nucleophiles.